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Table 2 Treatment characteristics

From: Interventionally implanted port catheter systems for hepatic arterial infusion of chemotherapy in patients with colorectal liver metastases: A phase II-study and historical comparison with the surgical approach

 

Group A: Interventional

Group B: Surgical

p-value*

Intention of treatment:

   

   "adjuvant" after resection/ablation

10

9**

 

   palliative

31

31

 

Type of first HAI – chemotherapy:

   

   none (primary port failure)

0

2

 

   First-line FA/5-FU only

27

32

 

   First-line combination

14

6

0.046

   Switched to 2nd-line HAI

16

12

 

   Switched to 3rd-line HAI

3

2

 

   Received HAI with MMC (any line)

8

7

 

   Received HAI with L-OHP (any line)

16

1

< 0.001

   Received HAI and i.v. CPT-11 (any line)

9

0

< 0.001

Complications and revisions

   

   ≥ 1 complication

26

30

 

   ≥ 2 complications

9

11

 

   ≥ 1 revision

23

4

< 0.001

   ≥ 1 thrombolytic therapy

7

11

 

Reason for termination of HAI:

   

   regular/ongoing

12

4

0.029

   disease progression

19

14

 

   port complication

7

20

< 0.001

   chemotherapy-related toxicity

1

1

 

   withdrawal

2

0

 
  1. * only significant values are indicated
  2. ** 8 patients of group A and 7 patients of group B completed 6 courses of adjuvant treatment (see text for further details)
  3. FA = folinic acid; 5-FU = 5-fluorouracil; MMC = mitomycin C; L-OHP = oxaliplatin; CPT-11 = irinotecan
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