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Table 2 Treatment characteristics

From: Interventionally implanted port catheter systems for hepatic arterial infusion of chemotherapy in patients with colorectal liver metastases: A phase II-study and historical comparison with the surgical approach

  Group A: Interventional Group B: Surgical p-value*
Intention of treatment:    
   "adjuvant" after resection/ablation 10 9**  
   palliative 31 31  
Type of first HAI – chemotherapy:    
   none (primary port failure) 0 2  
   First-line FA/5-FU only 27 32  
   First-line combination 14 6 0.046
   Switched to 2nd-line HAI 16 12  
   Switched to 3rd-line HAI 3 2  
   Received HAI with MMC (any line) 8 7  
   Received HAI with L-OHP (any line) 16 1 < 0.001
   Received HAI and i.v. CPT-11 (any line) 9 0 < 0.001
Complications and revisions    
   ≥ 1 complication 26 30  
   ≥ 2 complications 9 11  
   ≥ 1 revision 23 4 < 0.001
   ≥ 1 thrombolytic therapy 7 11  
Reason for termination of HAI:    
   regular/ongoing 12 4 0.029
   disease progression 19 14  
   port complication 7 20 < 0.001
   chemotherapy-related toxicity 1 1  
   withdrawal 2 0  
  1. * only significant values are indicated
  2. ** 8 patients of group A and 7 patients of group B completed 6 courses of adjuvant treatment (see text for further details)
  3. FA = folinic acid; 5-FU = 5-fluorouracil; MMC = mitomycin C; L-OHP = oxaliplatin; CPT-11 = irinotecan