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Table 4 GO and pathway annotation of genes and pathways altered in metastatic prostate cancer

From: Gene expression profiles of prostate cancer reveal involvement of multiple molecular pathways in the metastatic process

Probe ID Gene Symbol Overall FC FC_P1 FC_P2 FC_P3 FC_P4
Bone remodeling      
34342_s_at SPP1 24.7 24.16 26.78 4.75 5.39
2092_s_at SPP1 11.8 14.05 12.94 3.35 4.07
47958_r_at ANKH -2 -2.23 -2.31 -2.03 -3.66
65035_at TF1P11 -2.31 -2.28 -2.63 -2.97 -3.77
44596_at TWIST2 -2.45 -2.7 -2.12 -2.94 -2.35
40333_at BMP4 -2.5 -2.86 -2.89 -3 -5.23
49273_g_at BMP7 -2.81 -4.58 -4.89 -6.82 -13.13
Cell Adhesion      
34342_s_at SPP1 24.7 24.16 26.78 4.75 5.39
2092_s_at SPP1 11.8 14.05 12.94 3.35 4.07
64719_at FN1 7.5 27.07 6.02 4.05 4.93
59070_at HNT 5 5.37 9.69 12.08 13.67
62628_at PCDHGC3 3.4 2.24 5.44 2.97 2.42
44892_at MLLT4 3.3 2.63 2.07 6.21 7.48
47064_at HNT 3.27 2.98 4.37 8.07 8.4
66327_at PKP4 2.79 3.31 3.88 4.56 6.2
35246_at TYRO3 2.4 -5.43 -3.58 -6.35 -5.18
659_g_at THBS2 1.9 2.39 2.37 2.26 2.7
59623_at PCDH18 -2.22 -2.09 -2.89 -2.17 -2.39
53497_at ITGB8 -2.38 -2.88 -2.69 -3.51 -13.81
60876_at COL8A2 -2.38 -2.26 -3.26 -3.61 -2.25
47007_s_at NINJ2 -2.63 -2.55 -3.4 -3.3 -5.93
103_at THBS4 -2.7 -2.02 -3.37 -2.16 -3.26
46520_at ROBO2 -2.86 -2.58 -4.96 -4.14 -4.46
45939_at CNTN3 -3.33 -3.38 -2.14 -7.41 -11.94
47535_at CDH10 -3.7 -4.87 -3.19 -8.27 -4.65
56192_at PCDH7 -3.7 -2.5 -5.33 -5.74 -3
52999_at BOC -4.17 -2.42 -8.8 -12.25 -6.16
43930_at LSAMP -4.35 -3.05 -7.62 -9.76 -7.67
33883_at EFS -4.76 -5.43 -3.58 -6.35 -5.18
64342_at CTGF -5.26 -4.21 -4.15 -20.44 -14.87
64423_s_at BOC -6.67 -3.63 -8.16 -11.8 -54.66
52652_g_at COL8A2 -10 -7.95 -9.99 -11.56 -9.75
51214_at PKP1 -14.29 -11.57 -16.34 -11.83 -17.85
52140_at PGM5 -25 -23.87 -26.5 -44.27 -17.72
Cell_cycle      
47231_at DLG1 3.57 3.4 4.77 6.22 5.7
45574_g_at TPX2 3.49 11.09 2.57 3.24 8.6
54219_at 7-Sep 3.23 3.3 2.79 2.17 3.27
53998_at CLASP2 3.09 2.67 2.84 4.18 4.13
37933_at RBBP6 3.08 2.27 5.42 7.52 8.79
53568_at 7-Sep 2.97 3.94 2.4 3.53 2.49
51815_at TERF1 2.54 2.11 4.78 5.1 3.51
1797_at CDKN2D 2.41 3.65 2.76 2.46 2.47
50084_at DNCH1 2.29 2.42 2.15 2.11 2.29
66955_at EML4 2.13 2.22 3.3 6.8 5.09
1833_at CDK2 2.12 3.14 2.56 2.05 2.45
52744_at HRPT2 2.07 2.73 2.62 3.4 3.36
60568_at BCL2 2.07 2.18 3.27 3.35 3.75
41632_at E2F3 2.05 2.34 2.04 2.2 2.15
59821_at BCL2 1.87 2.89 3.13 3.58 3.86
36101_s_at VEGF 1.53 2.5 2.38 2.53 3.06
63158_at GRLF1 1.27 3.55 2.63 2.3 3.45
65908_at CHES1 -2.1 -3.3 -2.11 -2.34 -5.51
46664_at PYCARD -2.14 -2.36 -2.06 -2.94 -2.08
48980_at ZAK -2.25 -2.02 -4.8 -2.06 -2.07
36838_at KLK10 -2.38 -3.38 -2.94 -2.07 -6.13
50199_s_at RGC32 -2.73 -2.49 -3.64 -5.45 -4.17
39780_at PPP3CB -2.74 -3.82 -2.36 -3.06 -2.85
33864_at ZMYND11 -2.78 -4.77 -2.85 -3.79 -3.79
49504_r_at MCC -3.45 -5.9 -5.71 -5.08 -5.84
37005_at NBL1 -3.83 -3.34 -4.27 -4.31 -6.36
234_s_at PTN -3.86 -2.92 -5.02 -2.15 -3.33
37283_at MN1 -4.63 -4.47 -7.36 -5.55 -7.48
45217_at PDGFC -4.82 -4.32 -7.53 -8.81 -3.97
1005_at DUSP1 -6.16 -6.53 -16.66 -3.02 -3.19
36669_at FOSB -7.85 -8.81 -6.27 -7.6 -8.39
34820_at PTN -12.55 -11.62 -31.95 -10.24 -27.11
37430_at ALOX15B -21 -12.47 -12.41 -14.17 -9.1
Transcription      
1577_at AR 10 14.35 12.97 12.24 14.78
65001_r_at TBL1XR1 7 3.53 12.3 4.06 7.19
1578_g_at AR 6.18 7.56 4.86 5.32 6.37
42733_i_at FOXP1 5.6 2.61 5.92 14.54 14.09
52769_at POLR2A 5.1 2.93 4.04 12.61 11.14
54342_at ZNF605 4.55 2.75 6.89 4.85 4.04
65083_at RNPC2 4.1 3.18 3.96 6.01 9.19
42734_r_at FOXP1 3.5 2.01 4.49 7.53 8.6
48423_at ZNF621 3.4 2.11 8.51 3.74 7.33
51543_at ZNF395 3.32 2.99 5.52 6.73 6.51
44546_at ZNF148 3 3.32 2.59 4.72 4.18
49633_at HES6 3 5.76 2.26 2.34 6.72
51842_at CBX4 3 3.32 2.61 5.21 3.08
54981_r_at SFPQ 3 2.27 4.87 4.9 5.33
60076_at SOX4 3 3.32 3.77 2.09 2.72
43580_at MORF4L2 2.93 2.42 3.49 3.38 6.52
34715_at FOXM1 2.84 6.82 2.17 2.9 2.99
40674_s_at HOXC6 2.81 3.09 2.48 6.67 4.56
56981_at ZKSCAN1 2.77 2.65 2.4 2.6 4.04
55293_at ADNP 2.73 2.44 3.6 3.98 3.9
43545_at ZNF281 2.7 2.17 3.21 3.05 4.19
32653_at BRD8 2.56 2.11 3.73 3.22 4.45
53846_at FLJ21616 2.55 3.1 2.96 5.41 5.92
45953_at NCOA1 2.42 6.53 4.13 3.58 6.06
46006_at ERCC8 2.35 2.35 2.7 3.36 5.84
50911_at RLF 2.35 2.18 2.38 4.07 4.92
58641_at MAML3 2.33 2.86 2.31 5.61 5.44
42571_at MORF4L2 2.32 2.21 3.7 3.99 3.48
43120_at MLL3 2.32 2.55 2.48 2.14 2.74
31437_r_at ESR2 2.3 2.06 3.06 3.13 4.09
50532_at JARID1A 2.3 3.22 3.32 3.54 4.12
44939_at MLL3 2.22 2.55 2.48 2.14 2.74
55502_at FOXO3A 2.21 2.44 3.6 3.98 3.9
52328_at SP3 2.2 2.13 2.62 3.38 3.11
54220_r_at NLK 2.16 2.39 4.23 3.94 4.41
41632_at E2F3 2.04 2.34 2.04 2.2 2.15
66313_at HIPK1 2 2.09 2.85 2.95 3.98
42193_r_at --- 1.9 2.16 2.04 2.66 3.29
39540_at ZBTB7A 1.89 2.42 3.27 3.03 2.61
63158_at GRLF1 1.79 3.55 2.63 2.3 3.45
65908_at CHES1 -2.13 -3.3 -2.11 -2.34 -5.51
36770_at STAT2 -2.17 -2.3 -3.47 -2.82 -3.75
64963_at EYA4 -2.17 -3.06 -3.31 -2.55 -5.01
65945_at PNRC2 -2.17 -2.08 -2.26 -2.61 -2.24
1454_at SMAD3 -2.27 -2.17 -2.51 -2.02 -2.07
54658_at PSPC1 -2.33 -3.18 -2.22 -3.63 -13.16
44596_at TWIST2 -2.5 -2.7 -2.12 -2.94 -2.35
46704_at KLF3 -2.63 -2.38 -2.29 -2.19 -3.33
51253_at ZBTB4 -2.63 -2.92 -3.18 -2.63 -3.93
287_at ATF3 -2.78 -2.11 -2.33 -2.63 -3.3
33864_at ZMYND11 -2.78 -4.77 -2.85 -3.79 -3.79
63526_f_at KLF6 -2.78 -3.21 -2.48 -2.71 -3.33
64932_at VPS36 -2.86 -4.56 -2.88 -2.48 -2.27
45680_at ZNF537 -2.94 -2.77 -3.37 -2.78 -3.74
43431_at SOX2 -3.03 -2.09 -3.8 -7.43 -7.34
47620_at XAB2 -3.33 -2.7 -8.25 -7.6 -8.49
465_at HTATIP -3.45 -2.52 -2.37 -4.49 -2.47
37863_at EGR2 -4.55 -7.7 -5.52 -7.23 -15.41
48587_at KLF4 -4.76 -3.77 -3.62 -4.57 -12.5
36634_at BTG2 -5.26 -6.99 -3.13 -9.25 -5.22
279_at NR4A1 -6.25 -5.31 -8.04 -5.11 -8.48
280_g_at NR4A1 -7.14 -8.68 -13.49 -5.82 -8.58
40375_at EGR3 -8.33 -9.89 -7.71 -8.49 -6.44
53766_at PER3 -9.09 -15.43 -6.79 -5.56 -6.29
MAP Kinase Pathway      
1562_g_at DUSP8 5.8 2.42 5.01 16.6 5.86
1104_s_at HSPA1A/HSPA1B 4.1 7.81 2.77 2.81 5.02
51474_at MAP4K4 3.57 4.86 4.32 8.7 8.52
60658_at --- 3.5 -3 -2.96 -3.6 -3.73
50375_at SOS1 3 2.97 4.08 4.57 3.79
33855_at GRB2 2.55 2.29 2.61 3.85 2.1
42838_f_at MAP3K8 2.3 2.25 3.4 2.78 2.08
54220_r_at NLK 2.16 2.39 4.23 3.94 4.41
790_at NGFB 1.86 2.08 2.35 3.37 2.9
48980_at ZAK -2.27 -2.02 -4.8 -2.06 -2.07
43053_g_at PAK1 -2.7 -6.31 -2.46 -2.83 -2.11
39780_at PPP3CB -2.78 -3.82 -2.36 -3.06 -2.85
468_at FGF13 -2.78 -4.35 -4.35 -2.11 -2.56
65904_at --- -2.94 -2.05 -3.48 -4.18 -3.43
1292_at DUSP2 -3.13 -3.72 -3.66 -3.17 -2.19
57299_s_at RRAS -3.23 -3 -2.96 -3.6 -3.73
1970_s_at FGFR2 -5.56 -2.55 -13.13 -8.88 -4.92
1005_at DUSP1 -6.25 -6.53 -16.66 -3.02 -3.19
279_at NR4A1 -6.25 -5.31 -8.04 -5.11 -8.48
280_g_at NR4A1 -7.14 -8.68 -13.49 -5.82 -8.58
1916_s_at FOS -7.69 -7.58 -21.81 -6.93 -11.58
1915_s_at FOS -9.09 -7.59 -26.38 -11.03 -12.11
2094_s_at FOS -16.67 -10.72 -25.75 -13.72 -16.45
  1. Genes whose median value shows at least 2 fold change in every metastatic patient were annotated by NIH's DAVID tool. Genes belonging to selected GO categories with a significant number of differentially expressed genes are shown. Overall_FC, the fold change in the mean expression value of all metastatic samples compared to the primary samples;FC_P1, FC_P2, FC_P3, FC_P4; a patient-specific median expression value was calculated using all the samples from each patient. This was compared to the median value for the primary tumors. Patient P4 had only sample and this was considered the median.