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Table 2 Genes differentially expressed between normal lobular versus normal ductal cells by both rank products and pairwise analysis

From: Novel markers for differentiation of lobular and ductal invasive breast carcinomas by laser microdissection and microarray analysis

Probe Set1 Gene Symbol Gene Title Rank products Pairwise comparison
    Fold-change Incr/Decr
Regulation of transcription
229431_at RFXAP Regulatory factor X-associated protein -3.1 1/6
229732_at HSZFP36 ZFP-36 for a zinc finger protein -3.0 0/6
207117_at H-plk Krueppel-related zinc finger protein 2.4 6/1
Protein biosynthesis and modification
214130_s_at PDE4DIP Phosphodiesterase 4D interacting protein (myomegalin) -3.2 1/6
232752_at --- (LOXL1) ↓ CDNA FLJ10302 fis, clone NT2RM2000042 (lysyl oxidase-like 1) -1.4 1/6
Proteolysis and metabolism
49452_at ACACB Acetyl-Coenzyme A carboxylase beta -18 0/8
220419_s_at USP25 Ubiquitin specific peptidase 25 -2.9 1/6
220177_s_at TMPRSS3 Transmembrane protease, serine 3 -2.8 1/6
Ion transport
201735_s_at CLCN3 Chloride channel 3 -2.8 2/6
205044_at GABRP Gamma-aminobutyric acid (GABA) A receptor, pi -1.8 1/6
Actin binding
212650_at EHBP1 EH domain binding protein 1 2.6 6/0
GTPase activity
202975_s_at RHOBTB3 Rho-related BTB domain containing 3 2.5 7/1
203264_s_at ARHGEF9 Cdc42 guanine nucleotide exchange factor (GEF) 9 2.6 6/0
Regulation of cell development, activation, growth and motility
209890_at TSPAN5 Tetraspanin 5 2.6 7/0
Small leucine-rich proteoglycan (slrp) family
211896_s_at DCN Decorin 2.0 7/1
Protein kinase cascade
211081_s_at MAP4K5 Mitogen-activated protein kinase kinase kinase kinase 5 -2.3 1/7
Other
206157_at PTX3 Pentraxin-related gene, rapidly induced by IL-1 beta -2.8 2/7
218431_at C14orf133 Chromosome 14 open reading frame 133 -2.7 0/7
218514_at FLJ10587 Hypothetical protein FLJ10587 -2.6 1/7
226760_at LOC203411 Hypothetical protein LOC203411 3.0 6/2
  1. ↑ – upregulated in normal lobular cells; ↓ – downregulated in normal lobular cells
  2. 1Affymetrix probe set number; If there was more than one probe set for the particular gene found among top 20 changed genes (according to the fold change), the probe set with the highest fold change is used and number of other probe set is indicated.