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Figure 3 | BMC Cancer

Figure 3

From: Expression of the Na+/l-symporter (NIS) is markedly decreased or absent in gastric cancer and intestinal metaplastic mucosa of Barrett esophagus

Figure 3

Immunohistochemical analysis of NIS expression in human gastrointestinal tract. a: normal esophageal squamous epithelium (haematoxylin-eosin/HE/staining, original magnification 100×) b: normal esophageal squamous epithelium: negative for NIS expression (original magnification 100×) c: Barrett mucosa (HE staining, original magnification 100×) d: Barrett mucosa, junctional and fundus-type columnar metaplasia: NIS positive staining (original magnification 100×) e: Barrett mucosa with intestinal metaplasia (HE staining, original magnification 100×) f: Barrett mucosa with intestinal metaplasia: negative for NIS expression (original magnification 100×) g: squamous cell esophageal carcinoma (HE staining, original magnification 100×) h: squamous cell esophageal carcinoma: NIS negative staining (original magnification 100×) i: gastric carcinoma – signet ring cell – (HE staining, original magnification 200×) j: gastric carcinoma – signet ring cell – negative for NIS expression (original magnification 200×) k: on the border of the gastric adenocarcinoma, adjacent "normal" extratumoral mucosa: faint, focal NIS expression (original magnification 100×) I: at 1 cm from gastric adenocarcinoma: definite focal NIS staining (original magnification 400×) m: far from the gastric adenocarcinoma: strong, linear NIS expression (original magnification 400×) n: gastric polyp (HE staining, original magnification 100×) o: gastric polyp: NIS positive staining (original magnification 100×) p: gastric polyp (HE staining, original magnification 200×) q: gastric polyp with colon-type metaplasia: NIS negative staining (original magnification 200×) r: small bowel adenocarcinoma (HE staining, original magnification 100×) s: small bowel adenocarcinoma: NIS negative staining (original magnification 100×) t: normal large bowel mucosa: NIS negative staining (original magnification 100×) v: colon polyp (HE staining, original magnification 100×) w: colon polyp: NIS negative expression (original magnification 100×) x: adenocarcinoma of the colon (HE staining, original magnification 100×) y: adenocarcinoma of the colon: negative for NIS expression (original magnification 100×).

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