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Table 2 Selected studies of neoadjuvant chemoradiation.

From: Primary resection versus neoadjuvant chemoradiation followed by resection for locally resectable or potentially resectable pancreatic carcinoma without distant metastasis. A multi-centre prospectively randomised phase II-study of the Interdisciplinary Working Group Gastrointestinal Tumours (AIO, ARO, and CAO)

Study Institution Number of patients Total dose of XRT (Gy) Chemo-therapy (mg/m2) Median OS (months) 1(2,4,5)-year-OS-rate (%) Rate local recurrence (%) Rate of resectability (%) Rate of clear resections
Hoffman et al. 1998[39, 40] multi-centric 53 50.4 5-FU/MMC 9.7 all pts
15.7 res
2y: 27 res 24/53 (26 %)
3/24 (13%) res
24/53 (45%) n.a
Snady et al. 2000 [29]Mount Sinai 159
68* (20 res§)
91 adj
54 + 14 Gy 5-FU/cDDP/Streptozotocin 23.6* (32 res)
14.0
1 y: 86*(89)vs.64
2y: 58*(60) vs.32
3y: 27*(40)vs.17
n.a. 20/68 (29%)
-
95% neo
84% adj
Breslin et al. 2001 [20] MDACC 132 45 or 50.4 Gy
or 10 × 3 Gy ± IORT
5-FU, or Tax or Gem 21 1y: 75
2y: 40
5y: 23
8/132 (6%) - 88%
Sasson AR et al.2003 [28]FCCC 116
61 neo
55 adj
50.4 5-FU/MMC or Gem all 18
neo 23
adj 16
n.a. n.a. - 39%
n.a.
n.a.
White et al. 2005 [21]Duke 193
i.p.r.:102
i.l.f.: 91
45 + 5.4 Gy 5-FU or Gem 23
39 i.p.r.
20 i.l.f.
3y: 37 res
5y: 27 res
n.a. 70/193 (36%)
54/102 (53%)
16/91 (18%)
73%
n.a.
n.a.
  1. Abbreviations: 5-FU = 5-fluorouracil; adj = adjuvant therapy; cDDP = cisplatin; FCCC = Fox Chase Cancer Center, Philadelphia, PA; Gem = gemcitabine; Gy = Dose in Gray; i.p.r = initially potentially resectable; i.l.f. = initially locally advanced, MDACC = M.D. Anderson Cancer Center Houston, TX; MMC = mitomycin C; n.a. = not available; neo = neoadjuvant; OS = overall survival; res = resected patients, RT = radiotherapy; Tax = paclitaxel; vs. = versus. *initially unresectable patients ± resection after chemoradiation; § this study indicates overall survival as explained: (1) patients with chemoradiation (2) numbers in brackets: patients with chemoradiation and resection (3) right to 'vs.': patients after primary resection; § numbers in brackets in this row give results of the 20/68 resected patients with RCT.