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Table 4 Non-hematologic toxicities. All toxicities were grade 1–2 unless otherwise specified.

From: Phase I dose escalation study of vinorelbine and topotecan combination chemotherapy in patients with recurrent lung cancer

Cohort N = Treatment cycles (median) Fatigue Nausea/vomiting Constipation Alk Phos Cough/Dyspnea Hypo-kalemia Hyper-glycemia ↑ LFTs Diarrhea Neuropathy
1 3 12 (4) 2 1 2 1 0 1 2 0 1 1
2 3 11 (4) 2§ 4 1 0 0 0 3 1 1 2
3 3 18 (6) 6 8 2 3 4** 1 4 2 0 1
4 6 22 (4) 6 2 7 1 1 1 2 1 0 0
5 3 12 (4) 1 3 1 0 0 0 0 0 0 4
  1. §One patient with grade 4 fatigue. **One patient with grade 4 respiratory failure requiring intubation during cycle 2 only.
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