Table 4 Non-hematologic toxicities. All toxicities were grade 1–2 unless otherwise specified.
Cohort | N = | Treatment cycles (median) | Fatigue | Nausea/vomiting | Constipation | Alk Phos | Cough/Dyspnea | Hypo-kalemia | Hyper-glycemia | ↑ LFTs | Diarrhea | Neuropathy |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | 3 | 12 (4) | 2 | 1 | 2 | 1 | 0 | 1 | 2 | 0 | 1 | 1 |
2 | 3 | 11 (4) | 2§ | 4 | 1 | 0 | 0 | 0 | 3 | 1 | 1 | 2 |
3 | 3 | 18 (6) | 6 | 8 | 2 | 3 | 4** | 1 | 4 | 2 | 0 | 1 |
4 | 6 | 22 (4) | 6 | 2 | 7 | 1 | 1 | 1 | 2 | 1 | 0 | 0 |
5 | 3 | 12 (4) | 1 | 3 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 4 |