Table 3 Hematologic toxicities. Observed toxicities with vinorelbine/topotecan during all cycles of chemotherapy.
Cohort | N = | Treatment cycles (median) | Neutropenia | Thrombocytopenia | Anemia | |||||
|---|---|---|---|---|---|---|---|---|---|---|
|  |  |  | Grade 1–2 | Grade 3 | Grade 4 | FN | Grade 1–2 | Grade 3–4 | Grade 1–2 | Grade 3–4 |
1 | 3 | 12 (4) | 1 | 0 | 0 | 0 | 0 | 0 | 7 | 0 |
2 | 3 | 11 (4) | 9 | 0 | 0 | 0 | 1 | 0 | 3 | 0 |
3 | 3 | 18 (6) | 9 | 6 | 2* | 1* | 4 | 0 | 10 | 0 |
4 | 6 | 22 (4) | 7 | 8 | 1 | 0 | 7 | 0 | 14 | 0 |
5 | 3 | 12 (4) | 2 | 0 | 0 | 0 | 2 | 0 | 3 | 0 |