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Table 3 Hematologic toxicities. Observed toxicities with vinorelbine/topotecan during all cycles of chemotherapy.

From: Phase I dose escalation study of vinorelbine and topotecan combination chemotherapy in patients with recurrent lung cancer

Cohort N = Treatment cycles (median) Neutropenia Thrombocytopenia Anemia
    Grade 1–2 Grade 3 Grade 4 FN Grade 1–2 Grade 3–4 Grade 1–2 Grade 3–4
1 3 12 (4) 1 0 0 0 0 0 7 0
2 3 11 (4) 9 0 0 0 1 0 3 0
3 3 18 (6) 9 6 2* 1* 4 0 10 0
4 6 22 (4) 7 8 1 0 7 0 14 0
5 3 12 (4) 2 0 0 0 2 0 3 0
  1. * Occurred after cycle 1. Abbreviations: FN: febrile neutropenia.
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