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Table 3 Odds Ratios (95% CI) of gastric cancer for SNPs in metabolic genes according to smoking status and alcohol habits

From: Polymorphisms in metabolic genes, their combination and interaction with tobacco smoke and alcohol consumption and risk of gastric cancer: a case-control study in an Italian population

 

Never-smokers (57 cases, 146 controls)

Ever-smokers (50 cases, 108 controls)

p for heterogeneity

 

cases/controls

OR (95% CI) * †

cases/controls

OR (95% CI)

 

GSTM1 null

33/70

1.55 (0.83–2.90)

26/64

0.70 (0.35–1.39)

0.10

GSTT1 null

21/34

2.09 (1.06–4.11)

18/23

2.17 (1.02–4.59)

0.92

CYP1A1*2A

14/33

1.09 (0.53–2.27)

8/23

0.66 (0.27–1.61)

0.40

CYP2E1*5

4/11

0.86 (0.26–2.88)

1/9

0.20 (0.02–2.70)

0.24

CYP2E1*5A or *6

10/17

1.59 (0.67–3.79)

5/10

0.99 (0.31–3.13)

0.58

NAT2 Slow ‡

34/77

1.39 (0.74–2.60)

30/54

1.50 (0.75–2.98)

0.87

SULT1A1 His carriers

22/62

0.86 (0.45–1.64)

27/36

2.58 (1.27–5.25)

0.03

EPHX1 exon 3 His carriers

28/62

1.31 (0.70–2.46)

28/56

1.12 (0.57–2.22)

0.69

EPHX4 exon 4 Arg carriers

21/63

0.84 (0.44–1.60)

16/38

0.89 (0.43–1.85)

0.85

 

Never-drinkers (32 cases, 121 controls)

Ever-drinkers (73 cases, 133 controls)

p for heterogeneity

 

cases/controls

OR (95% CI)

cases/controls

OR (95% CI)

 

GSTM1 null

16/64

0.95 (0.43–2.10)

43/70

1.23 (0.69–2.20)

0.55

GSTT1 null

13/24

3.15 (1.32–7.47)

26/33

1.72 (0.92–3.22)

0.27

CYP2E1*5

0/10

-

5/10

0.86 (0.28–2.68)

-

CYP2E1*5A or *6

1/19

0.18 (0.22–1.46)

14/8

3.70 (1.45–9.37)

0.001

SULT1A1 His carriers

16/51

1.42 (0.63–3.17)

33/47

1.56 (0.86–2.82)

0.98

  1. * OR adjusted for age and gender
  2. † Reference groups are the homozygous wild genotypes for each gene
  3. ‡ Reference group is fast acetylators (homo-heterozygous for the wild-type allele)