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Table 3 Odds Ratios (95% CI) of gastric cancer for SNPs in metabolic genes according to smoking status and alcohol habits

From: Polymorphisms in metabolic genes, their combination and interaction with tobacco smoke and alcohol consumption and risk of gastric cancer: a case-control study in an Italian population

  Never-smokers (57 cases, 146 controls) Ever-smokers (50 cases, 108 controls) p for heterogeneity
  cases/controls OR (95% CI) * † cases/controls OR (95% CI)  
GSTM1 null 33/70 1.55 (0.83–2.90) 26/64 0.70 (0.35–1.39) 0.10
GSTT1 null 21/34 2.09 (1.06–4.11) 18/23 2.17 (1.02–4.59) 0.92
CYP1A1*2A 14/33 1.09 (0.53–2.27) 8/23 0.66 (0.27–1.61) 0.40
CYP2E1*5 4/11 0.86 (0.26–2.88) 1/9 0.20 (0.02–2.70) 0.24
CYP2E1*5A or *6 10/17 1.59 (0.67–3.79) 5/10 0.99 (0.31–3.13) 0.58
NAT2 Slow ‡ 34/77 1.39 (0.74–2.60) 30/54 1.50 (0.75–2.98) 0.87
SULT1A1 His carriers 22/62 0.86 (0.45–1.64) 27/36 2.58 (1.27–5.25) 0.03
EPHX1 exon 3 His carriers 28/62 1.31 (0.70–2.46) 28/56 1.12 (0.57–2.22) 0.69
EPHX4 exon 4 Arg carriers 21/63 0.84 (0.44–1.60) 16/38 0.89 (0.43–1.85) 0.85
  Never-drinkers (32 cases, 121 controls) Ever-drinkers (73 cases, 133 controls) p for heterogeneity
  cases/controls OR (95% CI) cases/controls OR (95% CI)  
GSTM1 null 16/64 0.95 (0.43–2.10) 43/70 1.23 (0.69–2.20) 0.55
GSTT1 null 13/24 3.15 (1.32–7.47) 26/33 1.72 (0.92–3.22) 0.27
CYP2E1*5 0/10 - 5/10 0.86 (0.28–2.68) -
CYP2E1*5A or *6 1/19 0.18 (0.22–1.46) 14/8 3.70 (1.45–9.37) 0.001
SULT1A1 His carriers 16/51 1.42 (0.63–3.17) 33/47 1.56 (0.86–2.82) 0.98
  1. * OR adjusted for age and gender
  2. † Reference groups are the homozygous wild genotypes for each gene
  3. ‡ Reference group is fast acetylators (homo-heterozygous for the wild-type allele)