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Table 5 Correlation between clinicopathological variables and survival-univariate analysis

From: Prognostic impact of clinicopathologic parameters in stage II/III breast cancer treated with neoadjuvant docetaxel and doxorubicin chemotherapy: paradoxical features of the triple negative breast cancer

    RFS OS
Variables   No. of Pt HR* (95% CI) p-value HR* (95% CI) p-value
Age <50 102 1 0.317 1 0.283
  ≥50 43 1.476 (0.688–3.166)   1.831 (0.606–5.533)  
Performance ECOG 0–1 139 1 0.686 1 0.888
  ECOG 2 6 1.349 (0.316–5.756)   1.160 (0.148–9.073)  
Initial clinical stage IIA, IIB, IIIA 93 1 0.017 1 0.010
  IIIB, IIIC 52 2.370 (1.116–4.815)   4.764 (1.462–15.525)  
pCR No 134 1 0.817 NA# NA#
  Yes 11 1.186 (0.281–5.005)    
Pathologic stage pCR~IIIA 113 1 0.288 1 0.086
  IIIB, IIIC 32 1.525 (0.700–3.319)   2.608 (0.874–7.786)  
Pathologic N stage N0 42 1 0.636 1 0.566
  N1–3 103 0.828 (0.378–1.812)   1.558 (0.342–7.099)  
Radiologic response Responder 100 1 0.515 1 0.683
  Non-responder 45 0.776 (0.361–1.665)   1.258 (0.419–3.775)  
Nuclear grade I, II 41 1 0.151 1 0.141
  III 87 1.894 (0.792–4.532)   2.689 (0.722–10.023)  
Histologic grade I, II 39 1 0.020 1 0.132
  III 82 4.159 (1.248–13.865)   4.820 (0.621–32.387)  
ER Positive 64 1 0.001 1 0.028
  Negative 81 5.410 (2.073–14.119)   9.921 (1.289–76.349)  
PR Positive 44 1 0.005 1 0.166
  Negative 101 7.778 (1.851–32.673)   4.278 (0.547–33.476)  
bcl-2 Positive 63 1 0.034 1 0.046
  Negative 74 2.351 (1.068–5.175)   4.705 (1.030–21.490)  
Ki-67 Low expression 56 1 0.038 1 0.082
  High expression 85 2.357 (1.050–5.287)   3.263 (0.861–12.363)  
p53 Low expression 67 1 0.869 1 0.670
  High expression 76 1.063 (0.515–2.193)   1.281 (0.410–3.998)  
c-erbB2 0/+/++ 107 1 0.242 1 0.678
  +++ 38 1.555 (0.742–3.255)   1.273 (0.408–3.973)  
Triple negative No 98 1 0.002 1 0.029
  Yes 47 3.148 (1.539–6.441)   3.430 (1.133–10.378)  
  1. RFS, relapse free survival; OS, overall survival; HR, hazard ratio; CI, confidence interval.
  2. *Hazard ratio was calculated by Cox's proportional hazard model. If the hazard ratio is greater than 1, the hazard ratio can be thought of as the average increased risk of relapse or dying at any point in time compared with the reference group (described upper line).
  3. #NA: Not available due to all censored in pCR.