Variables | Â | No. of Pts | Responders (RR %) | p-value* |
---|---|---|---|---|
Age | < 50 ≥ 50 | 102 43 | 69 (67.6) 31 (72.1) | 0.597 |
Performance | ECOG 0–1 ECOG 2 | 139 6 | 95 (68.3) 5 (83.3) | 0.666 |
Initial clinical stage | IIA, IIB, IIIA IIIB, IIIC | 93 52 | 64 (68.8) 36 (69.2) | 0.959 |
pCR | No | 134 | 89 (66.4) | 0.018 |
 | Yes | 11 | 11 (100.0) |  |
Nuclear grade | I, II | 41 | 22 (53.7) | 0.069 |
 | III | 87 | 61 (70.1) |  |
 | Unknown | 17 | - |  |
Histologic grade | I, II | 39 | 24 (61.5) | 0.741 |
 | III | 82 | 53 (64.6) |  |
 | Unknown | 24 | - |  |
ER | Positive | 64 | 41 (64.1) | 0.257 |
 | Negative | 81 | 59 (72.8) |  |
PR | Positive | 44 | 28 (63.6) | 0.360 |
 | Negative | 101 | 72 (71.3) |  |
bcl-2 | Positive | 63 | 45 (71.4) | 0.749 |
 | Negative | 74 | 51 (68.9) |  |
 | Unknown | 8 | - |  |
Ki-67 | Low expression# | 56 | 34 (60.7) | 0.066 |
 | High expression | 85 | 64 (75.3) |  |
 | Unknown | 4 | - |  |
p53 | Low expression# | 67 | 43 (64.2) | 0.219 |
 | High expression | 76 | 56 (73.7) |  |
 | Unknown | 2 | - |  |
c-erbB2 | 0/+/++ | 107 | 76 (71.0) | 0.368 |
 | +++ | 38 | 24 (63.2) |  |
Triple negative | No | 98 | 61 (62.2) | 0.012 |
 | Yes | 47 | 39 (83.0) |  |