Table 3 EGFR genotypes of cases and controls, and their association with the risk of lung cancer
Genotypes | Cases (n = 582), no. | Controls(n = 582), no. | P ‡ | Crude OR (95% CI) | Adjusted OR¶ (95% CI) | ||
|---|---|---|---|---|---|---|---|
M/F† | Overall(%) | M/F† | Overall(%) | ||||
127378C>T | |||||||
CC | 194/59 | 253 (43.5) | 196/61 | 257 (44.2) | 0.61 | 1.00 | 1.00 |
CT | 208/45 | 253 (43.5) | 216/44 | 260 (44.7) | 0.99(0.77–1.26) | 1.00(0.78–1.28) | |
TT | 65/11 | 76 (13.1) | 55/10 | 65 (11.2) | 1.19(0.82–1.73) | 1.22(0.83–1.78) | |
T allele | 0.348 | 0.335 | 0.51 | ||||
142285G>A | |||||||
GG | 166/40 | 206 (35.4) | 161/54 | 215 (36.9) | 0.80 | 1.00 | 1.00 |
GA | 218/61 | 279 (47.9) | 224/44 | 268 (46.1) | 1.09(0.84–1.40) | 1.11(0.86–1.44) | |
AA | 83/14 | 97 (16.7) | 82/17 | 99 (17.0) | 1.02(0.73–1.44) | 1.05(0.74–1.48) | |
A allele | 0.406 | 0.400 | 0.77 | ||||
162093G>A | |||||||
GG | 337/89 | 426 (73.2) | 343/86 | 429 (73.7) | 0.54 | 1.00 | 1.00 |
GA | 117/26 | 143 (24.6) | 117/28 | 145 (24.9) | 0.99(0.76–1.30) | 0.96(0.73–1.26) | |
AA | 13/0 | 13 (2.2) | 7/1 | 8 (1.4) | 1.64(0.67–3.99) | 1.60(0.65–3.97) | |
A allele | 0.145 | 0.138 | 0.63 | ||||
181946C>T | |||||||
CC | 195/47 | 242 (41.6) | 181/33 | 214 (36.8) | 0.04 | 1.00 | 1.00 |
CT | 221/47 | 268 (46.1) | 212/55 | 267 (45.9) | 0.89(0.69–1.14) | 0.89(0.69–1.15) | |
TT | 51/21 | 72 (12.4) | 74/27 | 101 (17.4) | 0.63(0.44–0.90)* | 0.59(0.41–0.85)** | |
CC+CT | 416/94 | 510 (87.6) | 393/88 | 481 (82.6) | 0.02 | 1.00 | 1.00 |
TT | 51/21 | 72 (12.4) | 74/27 | 101 (17.4) | 0.67(0.49–0.93)* | 0.63(0.45–0.88)***,**** | |
T allele | 0.354 | 0.403 | 0.01 | ||||
187114T>C | |||||||
TT | 162/42 | 204 (35.1) | 163/42 | 205 (35.2) | 0.78 | 1.00 | 1.00 |
TC | 215/54 | 269 (46.2) | 219/58 | 277 (47.6) | 0.98(0.76–1.26) | 1.01(0.78–1.31) | |
CC | 90/19 | 109 (18.7) | 90/15 | 100 (17.2) | 1.10(0.79–1.53) | 1.16(0.83–1.63) | |
C allele | 0.418 | 0.410 | 0.71 | ||||