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Table 3 EGFR genotypes of cases and controls, and their association with the risk of lung cancer

From: Polymorphisms in the epidermal growth factor receptor gene and the risk of primary lung cancer: a case-control study

Genotypes Cases (n = 582), no. Controls(n = 582), no. P Crude OR (95% CI) Adjusted OR (95% CI)
  M/F Overall(%) M/F Overall(%)    
127378C>T        
CC 194/59 253 (43.5) 196/61 257 (44.2) 0.61 1.00 1.00
CT 208/45 253 (43.5) 216/44 260 (44.7)   0.99(0.77–1.26) 1.00(0.78–1.28)
TT 65/11 76 (13.1) 55/10 65 (11.2)   1.19(0.82–1.73) 1.22(0.83–1.78)
T allele   0.348   0.335 0.51   
142285G>A        
GG 166/40 206 (35.4) 161/54 215 (36.9) 0.80 1.00 1.00
GA 218/61 279 (47.9) 224/44 268 (46.1)   1.09(0.84–1.40) 1.11(0.86–1.44)
AA 83/14 97 (16.7) 82/17 99 (17.0)   1.02(0.73–1.44) 1.05(0.74–1.48)
A allele   0.406   0.400 0.77   
162093G>A        
GG 337/89 426 (73.2) 343/86 429 (73.7) 0.54 1.00 1.00
GA 117/26 143 (24.6) 117/28 145 (24.9)   0.99(0.76–1.30) 0.96(0.73–1.26)
AA 13/0 13 (2.2) 7/1 8 (1.4)   1.64(0.67–3.99) 1.60(0.65–3.97)
A allele   0.145   0.138 0.63   
181946C>T        
CC 195/47 242 (41.6) 181/33 214 (36.8) 0.04 1.00 1.00
CT 221/47 268 (46.1) 212/55 267 (45.9)   0.89(0.69–1.14) 0.89(0.69–1.15)
TT 51/21 72 (12.4) 74/27 101 (17.4)   0.63(0.44–0.90)* 0.59(0.41–0.85)**
CC+CT 416/94 510 (87.6) 393/88 481 (82.6) 0.02 1.00 1.00
TT 51/21 72 (12.4) 74/27 101 (17.4)   0.67(0.49–0.93)* 0.63(0.45–0.88)***,****
T allele   0.354   0.403 0.01   
187114T>C        
TT 162/42 204 (35.1) 163/42 205 (35.2) 0.78 1.00 1.00
TC 215/54 269 (46.2) 219/58 277 (47.6)   0.98(0.76–1.26) 1.01(0.78–1.31)
CC 90/19 109 (18.7) 90/15 100 (17.2)   1.10(0.79–1.53) 1.16(0.83–1.63)
C allele   0.418   0.410 0.71   
  1. Male/Female.
  2. Two-sided χ2 test for either genotype distributions or allele frequencies between the cases and controls.
  3. ORs (95% CIs) were calculated by conditional logistic analysis, adjusted for pack-years of smoking.
  4. * P = 0.01.
  5. ** P = 0.005.
  6. *** P = 0.007.
  7. **** P = 0.32 for the interaction term between genotype and smoking status in the multivariate analysis.