Histological expression pattern of LASP-1. Immunohistochemical staining of LASP-1 (DAB, brown, magnification 100×) in different cell types. White arrows indicate LASP-1-negative nuclei, black arrows LASP-1-positive nuclei. (A) LASP-1 is highly overexpressed in physiologically proliferating epidermal basal cells, compared to superficial epidermal strata or dermal connective tissue cells. (B+C) LASP-1 is localized abundantly in nuclei of invasive breast cancer cells compared to LASP-1-negative nuclei of stromal cells. (D) Invasive breast cancer cells with LASP-1-negative nuclei but perinuclear and cytosolic LASP-1 overexpression. (E) Nuclear and cytosolic LASP-1-positive breast cancer cells in direct neighborhood to infiltrating LASP-1-negative lymphocytes.