Genetic polymorphisms of TLR3 are associated with Nasopharyngeal carcinoma risk in Cantonese population

BMC Cancer

Table 3 Haplotype frequencies of the TLR3 and effect of environmental factors revealed by Haplo.GLM

Model	Frequencies		P-value^a	OR(95%CI)^a
	Cases	Controls
Covariates
Sex			0.1705	0.530(0.214–1.31)
Age			0. 2019	0.975 (0.938–1.01)
VCA_IgA^b			< 0.0001	9.91 (6.17–15.9)
Haplotypes
Haplo-1 ATCT	0.0070	0.0151	0.0054	0.028 (0.002–0.341)
Haplo-2 ACTC	0.0797	0.1155	0.0587	0.363 (0.127–1.03)
Haplo-3 CCCC	0.1464	0.1132	0.5554	0.752 (0.292–1.94)
Haplo-4 ATTC	0.1753	0.2027	0.7950	1.10(0.528–2.30)
Haplo-5 ACCT	0.3839	0.3576	Not applicable	Reference
Haplo-6 ACCC	0.1782	0.1955	0.3789	1.40 (0.663–2.95)

Note: ^a P-values and ORs for haplotypes were adjusted by sex, age and VCA-IgA. ^b The P-values and OR for VCA-IgA was based on "per titer category" as indicated in Table 1.

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