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Table 3 Relation of MMP-1 genotypes to clinical parameters and environmental factors among the OSCC cases

From: The 2G allele of promoter region of Matrix metalloproteinase-1 as an essential pre-condition for the early onset of oral squamous cell carcinoma

  2G/2G n (%) 1G/2G n (%) 1G/1G n (%) p
Total 77 (45.3) 79 (46.5) 14 (8.2)  
Gender     
   Male 46 (45.9) 53 (47.5) 8 (7.4) 0.57
   Female 31 (47.2) 26 (41.3) 6 (7.5)  
Age     
   (years ± SD) 54.8 ± 15.1 57.5 ± 13.2 60.1 ± 10.9 0.277*
T category     
   T1-2 55 (45.1) 58 (47.5) 9 (7.4) 0.78
   T3-4 22 (45.8) 21 (43.8) 5 (10.4)  
N category     
   N0 50 (43.9) 53 (46.5) 11 (9.6) 0.607
   N1-3 27 (48.2) 26 (46.4) 3 (5.4)  
Tumor location     
   Tongue 45 (54.9) 31 (37.8) 6 (7.3) 0.260#
   Lower gingiva 14 (35) 24 (60) 2 (5)  
   Oral floor 6 (35.3) 9 (52.9) 2 (11.8)  
   Buccal mucosa 3 (21.4) 9 (64.3) 2 (14.3)  
   Upper gingiva 7 (53.8) 5 (38.5) 1 (7.7)  
   Palate 2 (50) 1 (25) 1 (25)  
Alcohol intake     
   Drinker 45 (45.9) 45 (45.9) 8 (8.2) 0.982
   Non-drinker 32 (44.4) 34 (47.2) 6 (8.3)  
Smoking status     
   Smoker 39 (44.3) 43 (48.8) 6 (6.8) 0.702
   Non-smoker 38 (46.3) 36 (43.9) 8 (9.8)  
  1. T and N categories were according to the UICC TNM classification of malignant tumors for lip and oral cavity. The data were analyzed by the χ2.
  2. * One-way ANOVA test.
  3. # Fisher's exact tests.