Assessment of free light chains in the cerebrospinal fluid of patients with lymphomatous meningitis – a pilot study

Table 1 Patients' characteristics

Patient	Gender	Age	LM	Diagnosis	CT/MRI	CSF cell count	CSF cytology	CSF-IC	Light chain on primary
1	W	46	Yes	CLL	LM	1054	Lymphocytes	Kappa	Kappa
2	W	47	Yes	LPL	Focal lesions	25	Lymphocytes	Kappa	Kappa
3	M	64	Yes	DLCL, Stage IV	N.D.	109	Lymphoblasts	N.D.	N.D.
4	M	65	Yes	LPL	LM	113	Lymphocytes	N.D.	Kappa
5	M	68	Yes	DLCL, Stage IVE	NEM	24	Lymphocytes	Kappa	Kappa
6	M	28	No	PTLPD, Stage IVE	NEM	<10	N.S.C.	N.D.	N.D.
7	M	29	No	FL Stage Ie (tonsil)	NEM	<10	N.S.C.	N.D.	N.D.
8	M	37	No	DLCL Stage II	NEM	<10	N.S.C.	N.D.	N.D.
9	M	46	No	DLCL, Stage IVE	NEM	23	N.S.C.	N.D.	Kappa
10	W	50	No	DLCL, Stage III	Focal Lesion	<10	N.S.C.	N.D.	N.D.
11	M	63	No	M. Hodgkin, Stage IV	N.D.	<10	N.S.C.	N.D.	No
12	W	66	No	Intracerebral PTLPD	Focal Lesion	119	Lymphocytes	CD 3	N.D.
13	W	66	No	Lymphoblastic T-NHL	N.D.	<10	N.S.C.	N.D.	No
14	M	73	No	Ocular Lymphoma	NEM	<10	N.S.C.	N.D.	N.D.
15	M	77	No	CLL, Parkinson's Disease	NEM	<10	N.S.C.	N.D.	No
16	M	79	No	M. Hodgkin, Stage III	NEM	27	N.S.C.	N.D.	No
17	M	82	No	DLCL St. IE (Spinal Cord)	N.D.	90	Lymphocytes	CD3	N.D.

LM – lymphomatous meningitis; CT – computed tomography; MRI – magnetic resonance imaging; CSF – cerebrospinal fluid; IC – immuncytochemistry, CLL – chronic lymphocytic leukaemia; DLCL – diffuse large cell lymphoma; LPL – lymphoplasmocytic lymphoma, PTLPD – post-transplantation lymphoproliferative disorder; FL – follicular lymphoma; T-NHL – Non-Hodgkin's Lymphoma of T-cell origin.
NEM – no evidence of lymphomatous meningitis; N.S.C. – no suspicious cells; N.D. – not done; EP-4 – epithelial cell surface marker

ISSN: 1471-2407