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Table 4 Significant genes in the Regulation of cell cycle pathway in ER-positive tumors

From: Pathway analysis of gene signatures predicting metastasis of node-negative primary breast cancer

Probe Set

z-score

DMFS

Gene Symbol

Gene Title

204817_at

3.73

-

ESPL1

extra spindle poles like 1 (S. cerevisiae)

38158_at

3.41

-

ESPL1

extra spindle poles like 1 (S. cerevisiae)

214710_s_at

3.10

-

CCNB1

cyclin B1

212426_s_at

3.08

-

YWHAQ

tyrosine 3-/tryptophan 5-monooxygenase activation protein

204009_s_at

3.08

-

KRAS

v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog

204947_at

3.04

-

E2F1

E2F transcription factor 1

201947_s_at

3.04

-

CCT2

chaperonin containing TCP1, subunit 2 (beta)

204822_at

2.91

-

TTK

TTK protein kinase

209096_at

2.57

-

UBE2V2

ubiquitin-conjugating enzyme E2 variant 2

204826_at

2.53

-

CCNF

cyclin F

212022_s_at

2.46

-

MKI67

antigen identified by monoclonal antibody Ki-67

202647_s_at

2.42

-

NRAS

neuroblastoma RAS viral (v-ras) oncogene homolog

201076_at

3.09

+

NHP2L1

NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)

201601_x_at

3.00

+

IFITM1

interferon induced transmembrane protein 1 (9–27)

204015_s_at

2.90

+

DUSP4

dual specificity phosphatase 4

220407_s_at

2.68

+

TGFB2

transforming growth factor, beta 2

206404_at

2.38

+

FGF9

fibroblast growth factor 9 (glia-activating factor)

  1. Genes were sorted based on their "z-score" (significance), reflecting their association with distant metastasis-free survival time ("DMFS") time.