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Table 3 Significant genes in the Apoptosis pathway in ER-positive tumors

From: Pathway analysis of gene signatures predicting metastasis of node-negative primary breast cancer

Probe Set z-score DMFS Gene Symbol Gene Title
208905_at 4.29 - CYCS cytochrome c, somatic
204817_at 3.73 - ESPL1 extra spindle poles like 1
38158_at 3.41 - ESPL1 extra spindle poles like 1
204947_at 3.04 - E2F1 E2F transcription factor 1
201111_at 3.04 - CSE1L CSE1 chromosome segregation 1-like
201636_at 2.97 - FXR1 fragile X mental retardation, autosomal homolog 1
220048_at 2.82 - EDAR ectodysplasin A receptor
210766_s_at 2.75 - CSE1L CSE1 chromosome segregation 1-like
221567_at 2.66 - NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
213829_x_at 2.65 - TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy
201112_s_at 2.57 - CSE1L CSE1 chromosome segregation 1-like
212353_at 2.51 - SULF1 sulfatase 1
208822_s_at 2.47 - DAP3 death associated protein 3
209462_at 2.37 - APLP1 amyloid beta (A4) precursor-like protein 1
203005_at 2.29 - LTBR lymphotoxin beta receptor (TNFR superfamily, member 3)
202731_at 4.01 + PDCD4 programmed cell death 4
206150_at 3.57 + TNFRSF7 tumor necrosis factor receptor superfamily, member 7
202730_s_at 3.18 + PDCD4 programmed cell death 4
209539_at 3.14 + ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
212593_s_at 3.07 + PDCD4 programmed cell death 4
204933_s_at 2.96 + TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
209831_x_at 2.43 + DNASE2 deoxyribonuclease II, lysosomal
203187_at 2.38 + DOCK1 dedicator of cytokinesis 1
210164_at 2.34 + GZMB granzyme B
  1. Genes were sorted based on their "z-score" (significance), reflecting their association with distant metastasis-free survival time ("DMFS") time.