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Table 6 Multivariate analysis for OS and PFS without RPA.

From: Concomitant treatment of brain metastasis with Whole Brain Radiotherapy [WBRT] and Temozolomide [TMZ] is active and improves Quality of Life

Overall Survival (OS) P value
Tumour control (SD, CR, PR) <0.0001
Brain progression (PD)  
KPS ≤60 0.002
KPS >60  
Age ≤65 years 0.01
Age >65 years  
Progression Free Survival (PFS) P value
Tumor control (SD, CR, PR) <0.0001
Brain progression (PD)  
KPS ≤60 0.003
KPS >60  
No extracranial disease 0.325
Extracranial disease  
Age >65 years 0.01
Age ≤65 years