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Table 1 Association between TGFB1 SNPs and breast cancer risk in the Nurses' Health Study

From: TGFB1 and TGFBR1 polymorphisms and breast cancer risk in the Nurses' Health Study

Genotype Cases (%) Controls (%) OR (95% CI)*
L10L (T/T) 469 (39.6) 613 (37.1) 1.00 (Ref.)
L10P (T/C) 548 (46.2) 797 (48.3) 0.87 (0.74 – 1.04)
P10P (C/C) 168 (14.2) 241 (14.6) 0.92 (0.72 – 1.17)
    p-trend = 0.27
-509 C/C 600 (50.2) 786 (47.3) 1.00 (Ref.)
-509 C/T 506 (42.3) 723 (43.5) 0.89 (0.76 – 1.05)
-509 T/T 89 (7.4) 154 (9.3) 0.76 (0.56 – 1.02)
    p-trend = 0.04
  1. *Unconditional logistic regression controlled for matching factors, family history of breast cancer, age at menopause, age at menarche, BMI at age 18, weight gain since age 18, age at first birth/parity, and personal history of benign breast disease