Association between the BRCA2N372H variant and male breast cancer risk: a population-based case-control study in Tuscany, Central Italy

Table 4 Distribution of 53 MBC with a time interval between diagnosis and interview ≤4 years and 261 male population controls according to the BRCA2 N372H genotype frequencies, stratified by age at diagnosis.

Genotype	Cases n	%	Controls n	%	Co-dominant model OR 95% CI	Recessive model OR 95% CI
≤60 years
N/N	6	35.3	94	54.0
N/H	6	35.3	68	39.1	1.38 (0.43; 4.47)
H/H	5	29.4	12	6.9	6.53 (1.73; 24.69)	5.63 (1.70;18.61)
Total	17	100.0	174	100.0
>60 years
N/N	18	50.0	33	37.9
N/H	12	33.3	39	44.8	0.56 (0.24;1.34)
H/H	6	16.7	15	17.2	0.73 (0.24;2.22)	0.96 (0.34;2.71)
Total	36	100.0	87	100.0

Odds Ratios (OR) and 95% Confidence Intervals according to co-dominant and recessive models estimated using logistic regression models. Interaction between BRCA2 N372H genotype and age: OR_interaction = 0.17 (95%CI = 0.04–0.83); p = 0.03.

ISSN: 1471-2407