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Table 4 Distribution of 53 MBC with a time interval between diagnosis and interview ≤4 years and 261 male population controls according to the BRCA2 N372H genotype frequencies, stratified by age at diagnosis.

From: Association between the BRCA2N372H variant and male breast cancer risk: a population-based case-control study in Tuscany, Central Italy

Genotype Cases n % Controls n % Co-dominant model OR 95% CI Recessive model OR 95% CI
≤60 years       
N/N 6 35.3 94 54.0   
N/H 6 35.3 68 39.1 1.38 (0.43; 4.47)  
H/H 5 29.4 12 6.9 6.53 (1.73; 24.69) 5.63 (1.70;18.61)
Total 17 100.0 174 100.0   
>60 years       
N/N 18 50.0 33 37.9   
N/H 12 33.3 39 44.8 0.56 (0.24;1.34)  
H/H 6 16.7 15 17.2 0.73 (0.24;2.22) 0.96 (0.34;2.71)
Total 36 100.0 87 100.0   
  1. Odds Ratios (OR) and 95% Confidence Intervals according to co-dominant and recessive models estimated using logistic regression models. Interaction between BRCA2 N372H genotype and age: ORinteraction = 0.17 (95%CI = 0.04–0.83); p = 0.03.