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Table 4 Multivariate analysis of cause-specific mortality based on 2,458 cases with complete pathological data

From: Prognostic value of histopathology and trends in cervical cancer: a SEER population study

  A   B  
  Model including tumor size and nodal variables   Model ignoring tumor size and nodal variables  
Variable Hazard ratio(6) (95% confidence interval) P Hazard ratio(6) (95% confidence interval) P
Pathology     
Histology (1)   <0.001   <0.001
   SCC microinvasive 1.26 (0.40–4.04) 0.693 0.61 (0.19–1.93) 0.407
   Carcinoma NOS 0.93 (0.40–2.17) 0.871 1.35 (0.60–3.06) 0.472
   Adenocarcinoma excl. mucinous 1.43 (1.07–1.90) 0.016 1.29 (0.97–1.72) 0.078
   Adenosquamous carcinoma 1.60 (1.14–2.24) 0.007 1.58 (1.13–2.22) 0.008
   Mucinous 1.94 (1.07–3.49) 0.028 2.08 (1.16–3.75) 0.015
   Small cell 7.03 (3.95–12.5) <0.001 7.59 (4.28–13.4) <0.001
Histological grade 3–4 (2) 1.56 (1.26–1.93) <0.001 1.83 (1.48–2.26) <0.001
Log tumor size (mm) (3) 1.89 (1.55–2.31) <0.001   
Log odds of nodal involvement (4) 1.26 (1.15–1.38) <0.001   
Stage     
   Historical stage localized (2)    0.24 (0.19–0.31) <0.001
   Stage II (5) 0.99 (0.62–1.58) 0.966   
   Stage III (5) 2.31 (1.70–3.14) <0.001   
   Stage IV (5) 2.57 (1.64–4.04) <0.001   
Other     
Year of diagnosis 0.97 (0.94–0.99) 0.016 0.96 (0.94–0.99) 0.011
African-American ethnicity (2) 1.47 (1.09–1.97) 0.011 1.55 (1.16–2.09) 0.004
Hysterectomy (2) 0.61 (0.47–0.80) <0.001 0.41 (0.32–0.52) <0.001
  1. (1) Reference level = non-microinvasive squamous cell carcinoma (SCC), all types.
  2. (2) Binarized variable, coded 1 versus all other levels of the variable including missing.
  3. (3) Untransformed tumor size displayed marked non-linearity.
  4. (4) Log ((number of positive nodes + 0.5)/(number of negative nodes + 0.5)) [14].
  5. (5) AJCC 3rd edition. Reference level = stage I.
  6. (6) Hazard ratio >1 indicates increased risk of dying from cervical cancer.