From: Prognostic value of histopathology and trends in cervical cancer: a SEER population study
 | A |  | B |  |
---|---|---|---|---|
 | Model including tumor size and nodal variables |  | Model ignoring tumor size and nodal variables |  |
Variable | Hazard ratio(6) (95% confidence interval) | P | Hazard ratio(6) (95% confidence interval) | P |
Pathology | Â | Â | Â | Â |
Histology (1) | Â | <0.001 | Â | <0.001 |
   SCC microinvasive | 1.26 (0.40–4.04) | 0.693 | 0.61 (0.19–1.93) | 0.407 |
   Carcinoma NOS | 0.93 (0.40–2.17) | 0.871 | 1.35 (0.60–3.06) | 0.472 |
   Adenocarcinoma excl. mucinous | 1.43 (1.07–1.90) | 0.016 | 1.29 (0.97–1.72) | 0.078 |
   Adenosquamous carcinoma | 1.60 (1.14–2.24) | 0.007 | 1.58 (1.13–2.22) | 0.008 |
   Mucinous | 1.94 (1.07–3.49) | 0.028 | 2.08 (1.16–3.75) | 0.015 |
   Small cell | 7.03 (3.95–12.5) | <0.001 | 7.59 (4.28–13.4) | <0.001 |
Histological grade 3–4 (2) | 1.56 (1.26–1.93) | <0.001 | 1.83 (1.48–2.26) | <0.001 |
Log tumor size (mm) (3) | 1.89 (1.55–2.31) | <0.001 |  |  |
Log odds of nodal involvement (4) | 1.26 (1.15–1.38) | <0.001 |  |  |
Stage | Â | Â | Â | Â |
   Historical stage localized (2) |  |  | 0.24 (0.19–0.31) | <0.001 |
   Stage II (5) | 0.99 (0.62–1.58) | 0.966 |  |  |
   Stage III (5) | 2.31 (1.70–3.14) | <0.001 |  |  |
   Stage IV (5) | 2.57 (1.64–4.04) | <0.001 |  |  |
Other | Â | Â | Â | Â |
Year of diagnosis | 0.97 (0.94–0.99) | 0.016 | 0.96 (0.94–0.99) | 0.011 |
African-American ethnicity (2) | 1.47 (1.09–1.97) | 0.011 | 1.55 (1.16–2.09) | 0.004 |
Hysterectomy (2) | 0.61 (0.47–0.80) | <0.001 | 0.41 (0.32–0.52) | <0.001 |