Skip to main content

Table 5 Combined analysis for XPC, XPD and XRCC3 polymorphisms and lung cancer risk estimates

From: Polymorphisms in XPC, XPD, XRCC1, and XRCC3 DNA repair genes and lung cancer risk in a population of Northern Spain

Genotype 1 Genotype 2 Cases n(%) Controls n(%) Adjusteda OR [95% CI] P P interaction
XPC PAT XPD Lys751Gln      
-/- Lys/Lys 72 (13.9) 84 (15.8) 1.00 (reference)   
+/+ Lys/Lys 36 (7.0) 38 (7.1) 1.10 [0.59–2.06] 0.971  
+/+ Lys/Gln 49 (9.5) 37 (6.9) 1.63 [0.89–2.98] 0.111  
+/+ Gln/Gln 16 (3.1) 9 (1.7) 2.25 [0.83–6.13] 0.202 0.202
XPC PAT XRCC3 Thr241Met      
-/- Thr/Thr 49 (12.2) 60 (13.8) 1.00 (reference)   
+/+ Thr/Thr 36 (8.9) 31 (7.1) 1.22 [0.61–2.43] 0.578  
+/+ Thr/Met 34 (8.4) 27 (6.2) 1.41 [0.68–2.92] 0.351  
+/+ Met/Met 12 (3.0) 6 (1.4) 3.06 [0.91–10.30] 0.071 0.174
XPD Lys751Gln XRCC3 Thr241Met      
Lys/Lys Thr/Thr 83 (20.6) 89 (20.5) 1.00 (reference)   
Gln/Gln Thr/Thr 17 (4.2) 17 (3.9) 0.98 [0.41–2.35] 0.968  
Gln/Gln Thr/Met 20 (5.0) 18 (4.1) 1.59 [0.70–3.59] 0.264  
Gln/Gln Met/Met 10 (2.5) 5 (1.2) 2.66 [0.74–9.62] 0.135 0.261
  1. a Adjusted by age, gender and cumulative tobacco consumption (in pack-years: ≤ 16.45, > 16.45–53 and > 53)