Table 3 Results of univariate and multivariate analysis

pT

2

24

100

0.226

3

255

85.6

2.2

4

31

83.0

6.9

grading

low-grade

257

86.9

2.2

0.446

high-grade

53

84.8

5

lymph node status

N0 or II

178

92.1

2.1

<0.001

or stage

N+ or III

132

79.5

3.5

vessel infiltration

V0

285

89.0

1.9

<0.001

V1

24

58.3

10.1

chemotherapy

applied

261

87.1

2.1

0.700

not applied

49

83.5

5.3

TGF-β1 in tumour

low (0–1)

209

85.5

2.5

0.462

high (2–3)

99

88.6

3.2

Smad3 in tumour

negative

133

88.1

2.9

0.941

positive

176

85.3

2.7

Smad4 in tumour

negative

44

92.5

4.2

0.896

positive

261

85.4

2.2

TGF-β-R1 in stroma

negative

122

83.8

3.4

0.121

positive

188

88.3

2.4

TGF-β R2 in stroma

negative

123

82.3

3.5

0.003

positive

186

89.3

2.3

score

n

relative risk RR

95% confidence intervall

p value

TGF-β R2 in stroma

negative

122

1

positive

186

2.2

1.2–3.8

0.007

lymph node status

N0

177

1

N+

131

2.1

1.2–3.8

0.012

vessel infiltration

V0

284

1

V1

24

4.1

2.1–7.9

<0.001