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Table 2 Intestinal permeability before and during the therapy

From: Gastrointestinal permeability in ovarian cancer and breast cancer patients treated with paclitaxel and platinum

parameter baseline (before therapy)
(mean ± SEM)
(95% CI)
(range)
after the first dose
(mean ± SEM)
(95% CI)
(range)
p (compared to baseline) mean of subsequent measurements
(mean ± SEM)
(95% CI)
(range)
p (compared to baseline) at the end of first or second cycle
(mean ± SEM)
(95% CI)
(range)
p (compared to baseline)
xylose (%) 17.1 ± 1.6
(13.9 – 20.2)
(0.8 – 45.3)
13.5 ± 1.5
(10.5 – 16.4)
(2.2 – 40.7)
0.03 16.2 ± 1.1
(14.0 – 18.5)
(4.2 – 35.5)
0.40 17.1 ± 1.6
(13.8 – 20.3)
(2.4 – 53.2)
0.41
mannitol (%) 11.4 ± 1.3
(8.8 – 14.0)
(0.5 – 34.2)
9.6 ± 0.9
(7.7 – 11.4)
(1.4 – 24.6)
0.21 13.1 ± 1.3
(10.4 – 15.9)
(2.0 – 36.2)
0.58 10.5 ± 1.0
(8.4 – 12.6)
(1.1 – 23.9)
0.16
sucrose (%) 0.41 ± 0.06
(0.30 – 0.52)
(0.05 – 1.40)
0.54 ± 0.07
(0.39 – 0.70)
(0.06 – 1.71)
0.06 0.47 ± 0.08
(0.30 – 0.64)
(0.08 – 2.51)
0.73 0.47 ± 0.09
(0.28 – 0.65)
(0.07 – 2.51)
0.43
lactulose (%) 0.57 ± 0.07
(0.42 – 0.73)
(0.06 – 2.40)
0.64 ± 0.07
(0.49 – 0.78)
(0.05 – 2.08)
0.46 0.56 ± 0.08
(0.41 – 0.72)
(0.12 – 2.19)
0.49 0.59 ± 0.10
(0.39 – 0.78)
(0.07 – 2.19)
0.30
lactulose/mannitol ratio 0.061 ± 0.006
(0.049 – 0.073)
(0.017 – 0.184)
0.101 ± 0.023
(0.055 – 0.147)
(0.010 – 0.770)
0.02 0.059 ± 0.006
(0.047 – 0.070)
(0.017 – 0.143)
0.54 0.058 ± 0.006
(0.045 – 0.071)
(0.009 – 0.136)
0.77
sucrose/mannitol ratio 0.038 ± 0.004
(0.030 – 0.046)
(0.008 – 0.098)
0.077 ± 0.017
(0.043 – 0.111)
(0.012 – 0.585)
0.004 0.048 ± 0.006
(0.035 – 0.061)
(0.008 – 0.154)
0.16 0.044 ± 0.006
(0.031 – 0.056)
(0.009 – 0.152)
0.37
lactulose/xylose ratio 0.039 ± 0.004
(0.030 – 0.047)
(0.014 – 0.139)
0.074 ± 0.016
(0.042 – 0.107)
(0.007 – 0.443)
0.004 0.041 ± 0.006
(0.027 – 0.054)
(0.008 – 0.166)
0.69 0.037 ± 0.006
(0.025 – 0.049)
(0.004 – 0.162)
0.90
sucrose/xylose ratio 0.024 ± 0.002
(0.019 – 0.029)
(0.004 – 0.061)
0.057 ± 0.011
(0.035 – 0.080)
(0.009 – 0.336)
0.001 0.034 ± 0.007
(0.020 – 0.048)
(0.004 – 0.186)
0.31 0.029 ± 0.006
(0.017 – 0.041)
(0.003 – 0.186)
0.74
  1. Shown is the mean ± standard error of the mean (SEM) of respective parameters. 95% confidence intervals (CI) of the mean are highlighted by the bold type, and range is indicated in the parenthesis below.