Table 1 Summary of statistical associations for leukemias and lymphomas with BRCA pathway mutations

MCL

ATM

OR = 123.75 [18.84–5056.6]

OR = 74.25 [9.34–3203.5]

OR = 297 [23.49–1311.9]

OR = 83.25 [12.9–3408.7]

OR = 81.00 [9.11–3582.4]

OR = 25.67 [3.66–1095.9]

OR = 57.32 (7.25 – 2490.3)

OR = 44 (3.57 – 2186.4)

OR = 44 (5.85 – 1898.9)

OR = 70.26 [34.59–142.72]

Lymphomas

NBS1

RR = 1860 [CI = 972.3–3467]

PLL

ATM

OR = 84.15 [11.43–3549.9]

OR = 165.00 [19.51–7007.2]

OR = 198 [19.02–8662]

OR = 137.11 [39.68 to 473.76]

ALL

ATM

OR = 16.16 [2.04–724.3]

OR = 25.55 [3.14–1144.6]

OR = 2.72 [0.86–10.1]

OR = 17.98 [5.37–60.18]

ALL

Fanconi anemia genes

RR = 13.26 [4.11–42.68]

RR = 10.76 [3.61–32.03]

ALL

NBS1

OR = 1.85 [CI = 1.42–2.25]

Leukemia before age 15

Fanconi anemia genes

RR = 227.4 [170.8–302.1]

RR = 127.4 [95.21–170.2]

CLL

ATM

OR = 46.59 [6.59–1972.5]

OR = 15.97 [1.66–762.5]

OR = 13.83 [2.11–580.4]

OR = 21.91 [6.57 to 73.09]

CLL

CHEK2 (I157T)

OR = 14.83 [1.85-infinite]

CLL

BRCA2 (N372H)

OR = 1.45 [1.13–1.86]

AML

Fanconi anemia genes

RR = 723.4 [385.7–1355.8]

RR= 684.8 [371.6–1261.8]

RR = 818.2 [2.37–287,689]

RR= 703.35 [363.7–1354.5]

AML

BRCA1

Association discussed in text