Table 2 Percentage and frequency of methylation [% (n)] of cancer-related genes in subtypes of renal cell carcinoma (RCC), oncocytoma, and morphologically normal renal tissue (NRT)
From: Quantitative promoter methylation analysis of multiple cancer-related genes in renal cell tumors
| Â | Â | Clear cell RCC | Papillary RCC | Chromophobe RCC | Oncocytoma | NRT |
|---|---|---|---|---|---|---|
Gene | Gene loci | % (n = 52) | % (n = 13) | % (n = 10) | % (n = 10) | % (n = 62) |
APC | 5q21-q22 | 19.2 (10) | 23.1 (3) | 0 (0) | 0 (0) | 8.1 (5) |
ARHI | 1p31 | 100 (52) | 100 (13) | 100 (10) | 100 (10) | 100 (62) |
CDH1 | 16q22.1 | 82.7 (43) | 69.2 (9) | 20 (2) | 30 (3) | 87.1 (54) |
CTNNB1 | 3p21 | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) |
SFN | 22q12.3 | 100 (52) | 100 (13) | 100 (10) | 100 (10) | 100 (62) |
ARF/p14 | 9p21 | 9.6 (5) | 7.7 (1) | 10 (1) | 20 (2) | 27.4 (17) |
CDKN2A/p16 | 9p21 | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) |
RASSF1A | 3p21.3 | 80.8 (42) | 100 (13) | 40 (4) | 90 (9) | 100 (62) |
GSTP1 | 11q13 | 5.8 (3) | 15.4 (2) | 0 (0) | 0 (0) | 0 (0) |
MDR1 | 7q21.1 | 86.5 (45) | 84.6 (11) | 80 (8) | 90 (9) | 96.8 (60) |
MTHFR | 1p36.3 | 100 (52) | 100 (13) | 100 (10) | 100 (10) | 100 (62) |
PTGS2 | 1q25.2-q25.3 | 96.1 (50) | 92.3 (12) | 90 (9) | 90 (9) | 100 (62) |
TIMP3 | 1p36.11 | 19.2 (10) | 23.1 (3) | 0 (0) | 0 (0) | 24.2 (15) |
ESR1 | 6q25.1 | 67.3 (35) | 76.9 (10) | 60 (6) | 80 (8) | 77.4 (48) |
ESR2 | 14q23.2 | 55.8 (29) | 46.1 (6) | 50 (5) | 30 (3) | 43.5 (27) |
FHIT | 3p14.2 | 51.9 (27) | 53.8 (7) | 50 (5) | 50 (5) | 69.3 (43) |
MGMT | 10q26 | 1.9 (1) | 0 (0) | 0 (0) | 0 (0) | 11.3 (7) |
RARβ2 | 3p24 | 1.9 (1) | 0 (0) | 0 (0) | 0 (0) | 0 (0) |