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Table 2 Percentage and frequency of methylation [% (n)] of cancer-related genes in subtypes of renal cell carcinoma (RCC), oncocytoma, and morphologically normal renal tissue (NRT)

From: Quantitative promoter methylation analysis of multiple cancer-related genes in renal cell tumors

   Clear cell RCC Papillary RCC Chromophobe RCC Oncocytoma NRT
Gene Gene loci % (n = 52) % (n = 13) % (n = 10) % (n = 10) % (n = 62)
APC 5q21-q22 19.2 (10) 23.1 (3) 0 (0) 0 (0) 8.1 (5)
ARHI 1p31 100 (52) 100 (13) 100 (10) 100 (10) 100 (62)
CDH1 16q22.1 82.7 (43) 69.2 (9) 20 (2) 30 (3) 87.1 (54)
CTNNB1 3p21 0 (0) 0 (0) 0 (0) 0 (0) 0 (0)
SFN 22q12.3 100 (52) 100 (13) 100 (10) 100 (10) 100 (62)
ARF/p14 9p21 9.6 (5) 7.7 (1) 10 (1) 20 (2) 27.4 (17)
CDKN2A/p16 9p21 0 (0) 0 (0) 0 (0) 0 (0) 0 (0)
RASSF1A 3p21.3 80.8 (42) 100 (13) 40 (4) 90 (9) 100 (62)
GSTP1 11q13 5.8 (3) 15.4 (2) 0 (0) 0 (0) 0 (0)
MDR1 7q21.1 86.5 (45) 84.6 (11) 80 (8) 90 (9) 96.8 (60)
MTHFR 1p36.3 100 (52) 100 (13) 100 (10) 100 (10) 100 (62)
PTGS2 1q25.2-q25.3 96.1 (50) 92.3 (12) 90 (9) 90 (9) 100 (62)
TIMP3 1p36.11 19.2 (10) 23.1 (3) 0 (0) 0 (0) 24.2 (15)
ESR1 6q25.1 67.3 (35) 76.9 (10) 60 (6) 80 (8) 77.4 (48)
ESR2 14q23.2 55.8 (29) 46.1 (6) 50 (5) 30 (3) 43.5 (27)
FHIT 3p14.2 51.9 (27) 53.8 (7) 50 (5) 50 (5) 69.3 (43)
MGMT 10q26 1.9 (1) 0 (0) 0 (0) 0 (0) 11.3 (7)
RARβ2 3p24 1.9 (1) 0 (0) 0 (0) 0 (0) 0 (0)