|
#
|
Sex
|
Ethnicity
|
Smoking Status
|
Histology
|
Source Tissue
|
Block Type1
|
Response2
|
EGFR Mutation
|
EGFR/CEP7
|
HER2/CEP17
|
EGFR Stratification3
|
HER2 Stratification3
|
|---|
|
9
|
F
|
Asian
|
N
|
adeno.
|
Cerebellum
|
Tissue Block
|
SD
|
Not Sequenced
|
2.1
|
1.9
|
High Poly.
|
Low Poly.
|
|
11
|
F
|
Asian
|
Unk.
|
adeno.
|
Lung
|
Tissue Block
|
PR
|
Exon 19 Del*, Exon 20 V774L
|
2.7
|
1.5
|
High Poly.
|
High Trisomy
|
|
27
|
F
|
Caucasian
|
Y
|
SCC
|
Lung
|
Tissue Block
|
PD
|
None
|
2.1
|
1.5
|
High Poly.
|
Low Poly.
|
|
34
|
M
|
Caucasian
|
Y
|
SCC
|
Lung
|
Tissue Block
|
SD
|
None
|
17.3
|
2.6
|
Gene Amp.
|
High Poly.
|
|
36
|
M
|
Asian
|
Y
|
adeno.
|
Pleura
|
Tissue Block
|
SD
|
None
|
2.0
|
2.0
|
Low Poly.
|
Low Poly.
|
|
40
|
M
|
Caucasian
|
Y
|
adeno.
|
Pleura
|
Cell Block
|
SD
|
None
|
3.1
|
1.4
|
High Poly.
|
Low Poly.
|
|
42
|
M
|
Caucasian
|
Y
|
adeno.
|
Lymph Node
|
Tissue Block
|
Unk.
|
None
|
2.1
|
2.3
|
Low Poly.
|
High Poly.
|
|
43
|
F
|
Caucasian
|
Y
|
adeno.
|
Lymph Node
|
Tissue Block
|
PD
|
None
|
2.7
|
0.9
|
High Poly.
|
Low Trisomy
|
|
44
|
F
|
Asian
|
N
|
adeno.
|
Pleura
|
Tissue Block
|
PR
|
Exon 20 S768I, Exon 20 L815L
|
1.9
|
2.9
|
Low Poly.
|
High Poly.
|
|
56
|
M
|
Caucasian
|
Y
|
adeno.
|
Lung
|
Tissue Block
|
Unk.
|
None
|
1.5
|
2.0
|
High Trisomy
|
Low Poly.
|
|
57
|
M
|
Caucasian
|
Y
|
adeno.
|
Lymph Node
|
Tissue Block
|
SD
|
None
|
1.6
|
2.2
|
Low Poly.
|
High Poly.
|
|
64
|
F
|
Caucasian
|
Y
| | | | | | | | | |
| | | |
Pre Rx:
|
adeno.
|
Lymph Node
|
Tissue Block
|
-
|
None
|
1.0
|
1.2
|
Low Trisomy
|
High Trisomy
|
| | | |
Post Rx:
|
adeno.
|
Pericaridium
|
Tissue Block
|
SD
|
None
|
2.2
|
1.3
|
Low Poly.
|
Low Trisomy
|
|
66
|
F
|
Asian
|
N
|
adeno.
|
Lung
|
Tissue Block
|
PR
|
Exon 19 Del*
|
2.9
|
1.2
|
High Poly.
|
Low Trisomy
|
- Patient data provided for samples displaying increased EGFR or HER2 copy number (Probe/CEP ratio > 2.0) or identified as FISH+ (High Polysomy or Gene Amplification)
- * = no mutations detected in normal tissue remaining after microdissection
- 1 = source of patient material (Tissue Block = microdissected formalin-fixed paraffin-embedded tissue block; Cell Block = whole section or microdissected formalin-fixed paraffin-embedded cell block; Cytology = scraped cytology slide)
- 2 = response as measured radiographically and defined by SWOG modification of the WHO criteria [20].
- PD = progressive disease, SD = stable disease, PR = partial response, Unk. = Unknown
- 3 = Copy number stratification as proposed by Cappuzzo et al [13]. (Disomy = < 2 copies in > 90% of cells, Low Trisomy = ≤2 copies in ≥40% of cells, 3 copies in 10–40% of cells, ≥4 copies in < 10% of cells, High Trisomy = ≤2 copies in ≥40% of cells, 3 copes in ≥40% of cells, ≥4 copes in < 10% of cells, Low Polysomy: ≥4 copies in 10–40% of cells, High Polysomy = ≥4 copies in 40% of cells, Gene Amplification = ≥15 copies in ≥10% of cells)
