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Table 4 EGFR and HER2 copy number alterations

From: Correlations of EGFR mutations and increases in EGFR and HER2 copy number to gefitinib response in a retrospective analysis of lung cancer patients

# Sex Ethnicity Smoking Status Histology Source Tissue Block Type1 Response2 EGFR Mutation EGFR/CEP7 HER2/CEP17 EGFR Stratification3 HER2 Stratification3
9 F Asian N adeno. Cerebellum Tissue Block SD Not Sequenced 2.1 1.9 High Poly. Low Poly.
11 F Asian Unk. adeno. Lung Tissue Block PR Exon 19 Del*, Exon 20 V774L 2.7 1.5 High Poly. High Trisomy
27 F Caucasian Y SCC Lung Tissue Block PD None 2.1 1.5 High Poly. Low Poly.
34 M Caucasian Y SCC Lung Tissue Block SD None 17.3 2.6 Gene Amp. High Poly.
36 M Asian Y adeno. Pleura Tissue Block SD None 2.0 2.0 Low Poly. Low Poly.
40 M Caucasian Y adeno. Pleura Cell Block SD None 3.1 1.4 High Poly. Low Poly.
42 M Caucasian Y adeno. Lymph Node Tissue Block Unk. None 2.1 2.3 Low Poly. High Poly.
43 F Caucasian Y adeno. Lymph Node Tissue Block PD None 2.7 0.9 High Poly. Low Trisomy
44 F Asian N adeno. Pleura Tissue Block PR Exon 20 S768I, Exon 20 L815L 1.9 2.9 Low Poly. High Poly.
56 M Caucasian Y adeno. Lung Tissue Block Unk. None 1.5 2.0 High Trisomy Low Poly.
57 M Caucasian Y adeno. Lymph Node Tissue Block SD None 1.6 2.2 Low Poly. High Poly.
64 F Caucasian Y          
    Pre Rx: adeno. Lymph Node Tissue Block - None 1.0 1.2 Low Trisomy High Trisomy
    Post Rx: adeno. Pericaridium Tissue Block SD None 2.2 1.3 Low Poly. Low Trisomy
66 F Asian N adeno. Lung Tissue Block PR Exon 19 Del* 2.9 1.2 High Poly. Low Trisomy
  1. Patient data provided for samples displaying increased EGFR or HER2 copy number (Probe/CEP ratio > 2.0) or identified as FISH+ (High Polysomy or Gene Amplification)
  2. * = no mutations detected in normal tissue remaining after microdissection
  3. 1 = source of patient material (Tissue Block = microdissected formalin-fixed paraffin-embedded tissue block; Cell Block = whole section or microdissected formalin-fixed paraffin-embedded cell block; Cytology = scraped cytology slide)
  4. 2 = response as measured radiographically and defined by SWOG modification of the WHO criteria [20].
  5. PD = progressive disease, SD = stable disease, PR = partial response, Unk. = Unknown
  6. 3 = Copy number stratification as proposed by Cappuzzo et al [13]. (Disomy = < 2 copies in > 90% of cells, Low Trisomy = ≤2 copies in ≥40% of cells, 3 copies in 10–40% of cells, ≥4 copies in < 10% of cells, High Trisomy = ≤2 copies in ≥40% of cells, 3 copes in ≥40% of cells, ≥4 copes in < 10% of cells, Low Polysomy: ≥4 copies in 10–40% of cells, High Polysomy = ≥4 copies in 40% of cells, Gene Amplification = ≥15 copies in ≥10% of cells)