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Table 2 Uptake of 10 μM [3H]troxacitabine and 10 μM [3H]uridine in four pancreatic adenocarcinoma cell lines.

From: Synergistic activity of troxacitabine (Troxatyl™) and gemcitabine in pancreatic cancer

Cell lines [3H]Troxacitabine [3H]Troxacitabine + 1 mM cold troxacitabine [3H]Uridine [3H]Uridine + 1 mM cold Uridine
Capan-2 10.2 ± 0.2 10.4 ± 0.1 1028 ± 74 65 ± 6
AsPc-1 19.3 ± 1.5 18.5 ± 1.4 6337 ± 183 326 ± 33
MIA PaCa-2 8.3 ± 0.3 8.2 ± 0.9 3070 ± 244 157 ± 1
Panc-1 12.7 ± 0.8 10.0 ± 0.7 2714 ± 302 158 ± 2
  1. Comparative uptake (4 h) of 10 μM [3H]troxacitabine and 10 μM [3H]uridine in four pancreatic adenocarcinoma cell lines in the absence or presence of excess non-radioactive (cold) nucleoside. Each value (pmol/106 cells) represents the mean (± SD) of three determinations.