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Table 2 Uptake of 10 μM [3H]troxacitabine and 10 μM [3H]uridine in four pancreatic adenocarcinoma cell lines.

From: Synergistic activity of troxacitabine (Troxatyl™) and gemcitabine in pancreatic cancer

Cell lines

[3H]Troxacitabine

[3H]Troxacitabine + 1 mM cold troxacitabine

[3H]Uridine

[3H]Uridine + 1 mM cold Uridine

Capan-2

10.2 ± 0.2

10.4 ± 0.1

1028 ± 74

65 ± 6

AsPc-1

19.3 ± 1.5

18.5 ± 1.4

6337 ± 183

326 ± 33

MIA PaCa-2

8.3 ± 0.3

8.2 ± 0.9

3070 ± 244

157 ± 1

Panc-1

12.7 ± 0.8

10.0 ± 0.7

2714 ± 302

158 ± 2

  1. Comparative uptake (4 h) of 10 μM [3H]troxacitabine and 10 μM [3H]uridine in four pancreatic adenocarcinoma cell lines in the absence or presence of excess non-radioactive (cold) nucleoside. Each value (pmol/106 cells) represents the mean (± SD) of three determinations.
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BMC Cancer

ISSN: 1471-2407

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