Pathway aberrations of murine melanoma cells observed in Paired-End diTag transcriptomes

BMC Cancer

Table 7 Differential gene expression between B16F1 melanoma cells and Melan-a2 melanocytes.

Category	1 (A)	2 (B)	3 (C)	4 (AB)	5 (AC)	6 (BC)	7 (ABC)	Total genes	Total transcripts
#Gene	1485	1229	1603	258	437	374	220	5606
#Melan-a2 melanocyte-specific tsc (A)	1678	0	0	299	549	0	351		2877
#B16F1 melanoma-specific tsc (B)	0	1409	0	323	0	473	382		2587
#Overlapped tsc (C)	0	0	1681	0	485	423	317		2906
									8370

Known genes expressed in Melan-a2 melanocytes and B16F1 melanoma cells are split into 7 categories based on the combination of their transcript types. Transcripts can be Melan-a2-specific (A), B16F1-specific (B), or common to both (C); the 7 categories represent all possible combinations. For example, each gene in category 1 expresses one or more transcript solely in melanocytes; each gene in category 4 expresses in both cell types but has no cross-library overlap in transcript type; and so on. 'tsc', transcript(s).

ISSN: 1471-2407