Reliability and validity of needle biopsy evaluation of breast-abnormalities using the B-categorization – design and objectives of the Diagnosis Optimisation Study (DIOS)

Table 2 Common causes of false-positive and negative diagnoses of screen-detected core biopsies [1]

Causes of false-positive diagnoses	- Sclerosing adenosis or radial scar mistakenly diagnosed as tubular carcinoma - Apocrine atypia in lobules, ducts, or sclerosing lesions mistakenly diagnosed as DCIS - Chronic inflammation mistakenly diagnosed as infiltrating lobular carcinoma - Invasion mistakenly diagnosed in DCIS - Radiotherapy effects mistakenly diagnosed as carcinoma
Causes of false-negative diagnoses	- Tubular carcinoma mistakenly diagnosed as sclerosing adenosis or radial scar - Infiltrating lobular carcinoma mistakenly interpreted as chronic inflammation or missed - Radiotherapy effect with missed foci of carcinoma - Metaplastic carcinoma mistakenly diagnosed as a stromal proliferation/fibroblastic scar

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