Graph: Tumor surface, time course. Y-axis: tumor surface (ATUM in mm2), x-axis: time in days after implantation. ANOVA on ranks (p = 0,016); *p < 0.05 versus day 7, #p < 0.05 versus Control, Mann-Whitney Rank Sum Test. Significant increase in two-dimensional tumor surface in both groups between days 7 and 28 after tumor implantation. Two-dimensional tumor surface is significantly reduced in animals treated with Celecoxib compared to Controls on day 28. A, B, C, D: Photographs of the cranial window with A 549 lung carcinoma, top-view, scale bar 1000 μm. Tumor borders marked by arrows. Day 7: Celecoxib (A), Control (C). Day 28: Celecoxib (B), Control (D).