Figure 4From: Evaluation of the kinase domain of c-KIT in canine cutaneous mast cell tumorsAmino acid alignment of the kinase domain (exons 16–20) of canine and human KIT. Canine and human amino acid alignments demonstrate a 99.5% identity between the phospho-transferase portion of the kinase domain of these species. Codon 816, which is commonly mutated in human mastocytosis patients (D816V; shaded residue) is also conserved in canine KIT.Back to article page