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Table 1 Genotype distributions for the health examination and patient groups.

From: Single nucleotide polymorphisms of the APC gene and colorectal cancer risk: a case-control study in Taiwan

Location DNA and amino acid change Validation Health examination group allele distribution Patient group allele distribution p*
exon 9 g.1050T>G SNP TT = 74 GG = 0 TT = 79 GG = 0 NS#
  silent unreported TG = 0 HW$ = 1 TG = 1 HW = 0.955  
exon 10 g.1378delG deletion GG = 74 -- = 0 GG = 79 -- = 0 NS
  p.E460fs unreported -G- = 0 HW = 1 -G- = 1 HW = 0.955  
exon 11 g.1458T>C SNP TT = 2 CC = 41 TT = 5 CC = 62 0.0012
  silent rs2229992§ CT = 31 HW = 0.169 CT = 13 HW = 0.002  
exon 11 g.1488A>T SNP AA = 73 TT = 0 AA = 80 TT = 0 NS
  silent rs9282599§ AT = 1 HW = 0.953 AT = 0 HW = 1  
exon 13 g.1635G>A SNP GG = 0 AA = 55 GG = 0 AA = 57 NS**
  silent rs351771§ AG = 19 HW = 0.205 AG = 23 HW = 0.133  
exon 15 g.3374T>C mutation TT = 73 CC = 0 TT = 77 CC = 0 NS
  p.V1125A unreported TC = 1 HW = 0.953 CT = 3 HW = 0.864  
exon 15 g.3378C>G mutation CC = 73 GG = 0 CC = 80 GG = 0 NS
  p.S1126R unreported CG = 1 HW = 0.953 CG = 0 HW = 1  
exon 15 g.4479G>A SNP GG = 2 AA = 49 GG = 0 AA = 69 0.0057
  silent rs41115§ AG = 23 HW = 0.718 AG = 11 HW = 0.509  
exon 15 g.4725A>G SNP AA = 74 GG = 0 AA = 79 GG = 0 NS
  silent unreported AG = 0 HW = 1 AG = 1 HW = 0.955  
exon 15 g.5034G>A SNP GG = 7 AA = 44 GG = 2 AA = 59 NS
  silent rs42427§ AG = 23 HW = 0.141 AG = 19 HW = 0.753  
exon 15 g.5268T>G SNP TT = 7 GG = 44 TT = 0 GG = 63 0.0023
  silent rs866006§ GT = 23 HW = 0.141 GT = 17 HW = 0.288  
exon 15 g.5465A>T SNP AA = 64 TT = 0 AA = 78 TT = 0 0.0145
  p.D1822V rs459552§ AT = 10 HW = 0.533 AT = 2 HW = 0.910  
exon 15 g.5880G>A SNP GG = 1 AA = 51 GG = 0 AA = 57 NS
  silent rs465899§ AG = 22 HW = 0.418 AG = 23 HW = 0.133  
  1. §:The refSNP IDs from NCBI RefSNP Clusters are listed under reported SNPs.
  2. $HW: p value of Hardy-Weinberg equilibrium obtained by Chi-square test.
  3. #NS: Not significant.
  4. *: The difference distribution of genotypes were examined by Chi-square test or Fisher's exact test.
  5. **: The p value was obtained by Chi-square test, and others by Fisher's exact test.