Genotype (female subjects only) | Total n = 96 | G/G n = 12 | G/T n = 43 | T/T n = 41 | Â |
---|---|---|---|---|---|
Number of subjects with ≥1 malignancy (%) | 71 (74.0%) | 10 (83.3%) | 30 (69.8%) | 31 (75.6%) | p = 0.61 |
No. of subjects with breast cancer (%) | 59 (61.5%) | 5 (41.7%) | 27 (62.8%) | 27 (65.8%) | p = 0.34 |
Mean age of onset of 1st breast cancer/years (range) | 41.6 (26–57) | 41.2 (29–49) | 38.6 (29–52) | 39.0 (26–57) | p = 0.80 |
No. of subjects with ovarian cancer (%) | 14 (14.6%) | 4 (33.3%) | 4 (9.3%) | 6 (14.6%) | p = 0.32 |
Mean age of onset of 1st ovarian cancer/years (range) | 58.0 (44–74) | 62.3 (51–74) | 60.3 (51–68) | 53.7 (44–66) | p = 0.32 |
Other malignancies | 3 | 1 plasmacytoma | 1 cervical cancer 1 uterine cancer | Â | Â |
No. of patients undergoing prophylactic bilateral oophorectomy | 10 | 0 | 5 | 5 | Â |
No. of patients undergoing bilateral risk reducing mastectomy | 3 | 1 | 1 | 1 | Â |