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Table 1 Incidence and age of onset of all malignancies, breast and ovarian cancer in carriers of pathogenic BRCA1 mutations genotyped for MDM2 SNP309 (p values refer to comparisons of frequencies between the G/G, G/T and T/T subgroups)

From: Influence of the MDM2 single nucleotide polymorphism SNP309 on tumour development in BRCA1 mutation carriers

Genotype (female subjects only) Total
n = 96
G/G
n = 12
G/T
n = 43
T/T
n = 41
 
Number of subjects with ≥1 malignancy (%) 71 (74.0%) 10 (83.3%) 30 (69.8%) 31 (75.6%) p = 0.61
No. of subjects with breast cancer (%) 59 (61.5%) 5 (41.7%) 27 (62.8%) 27 (65.8%) p = 0.34
Mean age of onset of 1st breast cancer/years (range) 41.6 (26–57) 41.2 (29–49) 38.6 (29–52) 39.0 (26–57) p = 0.80
No. of subjects with ovarian cancer (%) 14 (14.6%) 4 (33.3%) 4 (9.3%) 6 (14.6%) p = 0.32
Mean age of onset of 1st ovarian cancer/years (range) 58.0 (44–74) 62.3 (51–74) 60.3 (51–68) 53.7 (44–66) p = 0.32
Other malignancies 3 1 plasmacytoma 1 cervical cancer 1 uterine cancer   
No. of patients undergoing prophylactic bilateral oophorectomy 10 0 5 5  
No. of patients undergoing bilateral risk reducing mastectomy 3 1 1 1