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Table 3 Analysis of COX-2 8473T>C genotype frequencies, ORs and 95% CIs for adenocarcinoma by selected variables

From: Relationship between cyclooxygenase 8473T>Cpolymorphism and the risk of lung cancer: a case-control study

Variable Genotype, no (%)   
  Cases Controls OR (95% CI) for TC + CC vs TT
  TT TC CC TT TC CC Crude Adjusted
Gender
   Male 86 (68.2) 35 (27.8) 5 (4.0) 265 (56.8) 175 (37.5) 27 (5.8) 0.61 (0.40–0.93)a 0.59 (0.39–0.91)a,b
   Female 51 (64.6) 25 (31.7) 3 (3.8) 65 (56.5) 45 (39.1) 5 (4.4) 0.71 (0.40–1.29) 0.72 (0.40–1.30)b
Age (years)
   ≤60 69 (62.7) 39 (35.5) 2 (1.8) 158 (55.1) 115 (40.1) 14 (4.9) 0.73 (0.46–1.14) 0.74 (0.47–1.16)c
   >60 68 (71.6) 21 (22.1) 6 (6.3) 172 (58.3) 105 (35.6) 18 (6.1) 0.56 (0.34–0.92)a 0.55 (0.33–0.93)c,d
Smoking status
   Never 49 (61.2) 28 (35.0) 3 (3.8) 77 (55.8) 53 (38.4) 8 (5.8) 0.80 (0.46–1.40) 0.77 (0.43–1.36)c
   Everf 88 (70.4) 32 (25.6) 5 (4.0) 253 (57.0) 167 (37.6) 24 (5.4) 0.56 (0.36–0.85)g 0.57 (0.37–0.87)e,g
Pack-years in ever-smokersf
   ≤35 pys 46 (74.2) 14 (22.6) 2 (3.2) 147 (59.0) 89 (35.7) 13 (5.2) 0.50 (0.27–0.93)d 0.51 (0.27–0.96)e,h
   >35 pys 42 (66.7) 18 (28.6) 3 (4.8) 106 (54.4) 78 (40.0) 11 (5.6) 0.60 (0.33–1.08) 0.60 (0.33–1.10)e
  1. a P = 0.02.
  2. bAdjusted for age and pack-years of smoking.
  3. cAdjusted for gender and pack-years of smoking.
  4. d P = 0.03.
  5. eAdjusted for gender and age.
  6. fFormer- and current-smokers.
  7. g P = 0.01.
  8. h P = 0.04.