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Table 2 Distribution of COX-2 8473T>C genotype in controls and cases

From: Relationship between cyclooxygenase 8473T>Cpolymorphism and the risk of lung cancer: a case-control study

Genotype Control no. Case no. (SQ/AD/LA/SM)a Crude OR (95% CI)/Adjustedb OR (95% CI)
    All Cases SQa ADa SMa
TT 330 352 (152/137/4/59) 1.0 1.0 1.0 1.0
TC 220 205 (108/60/6/31) 0.87 (0.69–1.11)/0.87 (0.68–1.11) 1.07 (0.79–1.44)/1.06 (0.78–1.45) 0.66 (0.46–0.93)c/0.64 (0.45–0.91)d 1.22 (0.52–2.90)/1.13 (0.47–2.74)
CC 32 25 (10/8/0/7) 0.73 (0.43–1.26)/0.71 (0.41–1.23) 0.68 (0.33–1.42)/0.66 (0.31–1.42) 0.60 (0.27–1.34)/0.67 (0.29–1.50) 0.79 (0.49–1.26)/0.78 (0.48–1.26)
TC + CC 252 230 (118/68/6/38) 0.86 (0.68–1.08)/0.85 (0.67–1.07) 1.02 (0.76–1.36)/1.01 (0.75–1.37) 0.65 (0.47–0.91)d/0.64 (0.46–0.90)d 0.84 (0.54–1.31)/0.83 (0.53–1.30)
   Age    - 1.01 (0.99–1.03) 0.98 (0.97–1.00) 1.03 (1.00–1.05)e
   Gender (male: 0, female: 1)    _ 0.97 (0.55–1.69) 3.33 (2.09–5.32)f 1.01 (0.46–2.26)
   Pack-years of smoking    1.01 (1.01–1.02)f 1.03 (1.02–1.04)f 1.01 (1.00–1.02) 1.02 (1.01–1.03)f
  1. aSQ, squamous cell ca.; AD, adenoca.; LA, large cell ca.; and SM, small cell ca.
  2. bAdjusted for pack-years for all cases; and adjusted for age, gender and pack-years for SQ, AD and SM.
  3. c P = 0.02.
  4. d P = 0.01.
  5. e P = 0.04.
  6. f P < 0.001.