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Table 2 Distribution of COX-2 8473T>C genotype in controls and cases

From: Relationship between cyclooxygenase 8473T>Cpolymorphism and the risk of lung cancer: a case-control study

Genotype

Control no.

Case no. (SQ/AD/LA/SM)a

Crude OR (95% CI)/Adjustedb OR (95% CI)

   

All Cases

SQa

ADa

SMa

TT

330

352 (152/137/4/59)

1.0

1.0

1.0

1.0

TC

220

205 (108/60/6/31)

0.87 (0.69–1.11)/0.87 (0.68–1.11)

1.07 (0.79–1.44)/1.06 (0.78–1.45)

0.66 (0.46–0.93)c/0.64 (0.45–0.91)d

1.22 (0.52–2.90)/1.13 (0.47–2.74)

CC

32

25 (10/8/0/7)

0.73 (0.43–1.26)/0.71 (0.41–1.23)

0.68 (0.33–1.42)/0.66 (0.31–1.42)

0.60 (0.27–1.34)/0.67 (0.29–1.50)

0.79 (0.49–1.26)/0.78 (0.48–1.26)

TC + CC

252

230 (118/68/6/38)

0.86 (0.68–1.08)/0.85 (0.67–1.07)

1.02 (0.76–1.36)/1.01 (0.75–1.37)

0.65 (0.47–0.91)d/0.64 (0.46–0.90)d

0.84 (0.54–1.31)/0.83 (0.53–1.30)

   Age

  

-

1.01 (0.99–1.03)

0.98 (0.97–1.00)

1.03 (1.00–1.05)e

   Gender (male: 0, female: 1)

  

_

0.97 (0.55–1.69)

3.33 (2.09–5.32)f

1.01 (0.46–2.26)

   Pack-years of smoking

  

1.01 (1.01–1.02)f

1.03 (1.02–1.04)f

1.01 (1.00–1.02)

1.02 (1.01–1.03)f

  1. aSQ, squamous cell ca.; AD, adenoca.; LA, large cell ca.; and SM, small cell ca.
  2. bAdjusted for pack-years for all cases; and adjusted for age, gender and pack-years for SQ, AD and SM.
  3. c P = 0.02.
  4. d P = 0.01.
  5. e P = 0.04.
  6. f P < 0.001.