DEX inhibits therapy-induced carcinoma regression in vivo . MIA-Pa-Ca2 tumour cells were established as xenograft cell line and injected subcutaneously into nude mice treated as described in material and methods. The volumes of the fast-growing tumours are shown from day one to five after start of cisplatin therapy. Data are presented as mean of 5-6 animals and the single measurements are indicated. Statistical analysis: The P-value of 0.0063 for the CO versus CIS versus DEX versus CIS/DEX was determined according to the Koziol test for tumour growth curve analyses .