Tumor incidence in transgenic mice. (A) Kaplan-Meier analysis of the occurrence of mammary gland tumors in female wild type (WT), cortactin transgenic (T16), cyclin D1 transgenic (MP1) and cortactin/cyclin D1 bitransgenic (T16*MP1) mice as indicated by % mammary tumor free. No significant differences were seen. The age at which 50% of the animals were found to have mammary gland tumors, the T50, is for each mouse line more than 100 weeks. n, number of mice examined; +, indicates those mice that died without a MG tumor (censored). (B) Kaplan-Meier analysis determining the survival ratio of wild type and transgenic mice. MP1 and T16*MP1 were significantly different from WT (p = 0,034 and p = 0,017 respectively, log-rank test).