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Table 2 Adverse events (all grades) by treatment arm

From: Tolerability of intensified intravenous interferon alfa-2b versus the ECOG 1684 schedule as adjuvant therapy for stage III melanoma: a randomized phase III Italian Melanoma Inter-group trial (IMI – Mel.A.) [ISRCTN75125874]

  Number of patients (%)
  DD/DI arm (N = 86) HDI arm (N = 80)
Event Grade 1 Grade 2 Grade 3 Grade 4 Grade 1 Grade 2 Grade 3 Grade 4
Flu-like symptoms                 
Fatigue 19 (22) 26 (30) 25 (29) 0   14 (17) 27 (34) 19 (24) 3 (4)
Fever 28 (33) 33 (38) 7 (8) 0   25 (31) 23 (29) 8 (10) 1 (1)
Rigors/chills 15 (17) 5 (6) 0   0   12 (15) 3 (4) 3 (4) 0  
Arthralgia/myalgia 26 (30) 17 (20) 1 (1) 0   29 (36) 12 (15) 3 (4) 1 (1)
Sweating 8 (9) 3 (3) 0   0   8 (10) 1 (1) 1 (1) 0  
Gastrointestinal                 
Nausea/vomiting 32 (37) 12 (14) 2 (2) 0   27 (34) 12 (15) 1 (1) 0  
Constipation 13 (15) 5 (6) 0   0   9 (11) 3 (4) 0   0  
Diarrhea 11 (13) 1 (1) 0   0   5 (6) 1 (1) 1 (1) 1 (1)
Anorexia 30 (35) 10 (12) 3 (3) 0   14 (17) 12 (15) 6 (7) 0  
Hematological                 
Leukopenia 13 (15) 32 (37) 21 (24) 0   28 (35) 25 (31) 7 (9) 0  
Anemia 12 (14) 0   1 (1) 0   16 (20) 3 (4) 0   0  
Granulocytopenia 7 (8) 21 (24) 31 (36) 7 (8) 13 (16) 23 (29) 21 (26) 2 (2)
Platelets 11 (13) 1 (1) 3 (3) 1 (1) 16 (20) 5 (6) 0   0  
Hemorrhage 2 (2) 4 (5) 0   0   1 (1) 1 (1) 0   0  
Hepatic function                 
Bilirubin 3 (3) 2 (2) 0   0   6 (7) 0   0   0  
SGOT/SGPT 16 (19) 11 (13) 18 (21) 15 (17) 21 (26) 24 (30) 18 (22) 3 (4)
Alkaline phosphatase 8 (9) 2 (2) 0   0   8 (10) 3 (4) 0   0  
Liver dysfunction 0   2 (2) 1 (1) 0   3 (4) 1 (1) 1 (1) 0  
Neurologic                 
Depression/anxiety 19 (22) 14 (16) 7 (8) 0   20 (25) 12 (15) 12 (15) 1 (1)
Cognitive disturbance 10 (12) 10 (12) 4 (5) 0   10 (12) 7 (9) 2 (2) 0  
Cardiovascular                 
Hypertension 6 (7) 1 (1) 0   0   2 (2) 1 (1) 2 (2) 0  
Hypotension 1 (1) 1 (1) 0   0   5 (6) 4 (5) 0   0  
Ritmo 0   2 (2) 0   0   1 (1) 1 (1) 0   0  
Cardiac dysfunction 6 (7) 4 (5) 0   0   7 (9) 6 (7) 2 (2) 1 (1)
Pulmonary                 
Dyspnea 8 (9) 3 (3) 0   0   13 (16) 4 (5) 0   0  
Cough 7 (8) 1 (1) 0   0   13 (16) 1 (1) 0   0  
Dermatology                 
Skin 15 (17) 7 (8) 4 (5) 0   15 (19) 11 (14) 2 (2) 1 (1)
Local 1 (1) 0   1 (1) 0   5 (6) 1 (1) 1 (1) 0  
Metabolic                 
Hyperglycaemia 7 (8) 3 (3) 3 (3) 0   5 (6) 3 (4) 0   0  
Hypoglycaemia 1 (1) 2 (2) 4 (5) 2 (2) 1 (1) 3 (4) 0   1 (1)