From: Signs of positive selection of somatic mutations in human cancers detected by EST sequence analysis
EST source | Total number of substitutions (N) | Number of synonymous substitutions (Ns) | Number of non-synonymous substitutions (Na) | Number of nonsense substitutions (Nns) | Ns/Na | Nns/N | Ns exp | Na exp | Nns exp | Ns/Na exp | Nns/N exp | p_value χ2 Ns/Na observed vs expected | p_value χ2 Nns/N observed vs expected |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Normal | 429070 | 131244 | 286416 | 11410 | 0.46 | 0.027 | 111827 | 301723 | 15521 | 0.37 | 0.036 | <10^{-10} | <10^{-10} |
Cancer | 253254 | 74090 | 172551 | 6613 | 0.43 | 0.026 | 64719 | 179818 | 8717 | 0.36 | 0.034 | <10^{-10} | <10^{-10} |