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Table 1 Putative somatic mutations in cancer and normal ESTs.

From: Signs of positive selection of somatic mutations in human cancers detected by EST sequence analysis

EST source Total number of substitutions (N) Number of synonymous substitutions (Ns) Number of non-synonymous substitutions (Na) Number of nonsense substitutions (Nns) Ns/Na Nns/N Ns exp Na exp Nns exp Ns/Na exp Nns/N exp p_value χ2 Ns/Na observed vs expected p_value χ2 Nns/N observed vs expected
Normal 429070 131244 286416 11410 0.46 0.027 111827 301723 15521 0.37 0.036 <10-10 <10-10
Cancer 253254 74090 172551 6613 0.43 0.026 64719 179818 8717 0.36 0.034 <10-10 <10-10