Distribution of non-synonymous substitutions in cancer and normal ESTs. from the protein tyrosine phosphatase IV A2 gene. The substitutions are shown in the form of amino acid replacements. Identical letters in the same position correspond to substitutions from different EST libraries. The alignments were constructed using the MACAW program . Species name abbreviations: CANFA, Canis familiaris, GALGA, Gallus gallus, HOMSA, Homo sapiens, RATNO, Rattus norvegicus, XENTR, Xenopus tropicalis. TETNI, Tetraodon nigrovirides.