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Table 2 Statistical analysis of MDR-1 expression and associated clinic-pathological findings in RCCs. The statistical evaluation of immunohistochemical results has been compared to clinical reports, pathological findings and follow-up data. No statistically significant correlation between MDR-1 expression and sex, age, tumour size, tumour stage and histological grade has been obtained.

From: Prognostic significance of multidrug-resistance protein (MDR-1) in renal clear cell carcinomas: A five year follow-up analysis

Variables N. Score 1 Score 2 Score 3 MEAN ± SEM
Cases 30 19 7 4  
Age      
< 65 years 20 12 5 3 1,55 ± 0,17
> 65 years 10 7 2 1 1,40 ± 0,22
Sex      
Male 21 14 4 3 1,48 ± 0,16
Female 9 5 3 1 1,56 ± 0,24
Tumour Size      
≤ 7 cm 17 13 2 2 1,35 ± 0,17
> 7 cm 13 6 5 2 1,69 ± 0,21
Grading      
G1 6 5 0 1 1,33 ± 0,33
G2 17 11 4 2 1,47 ± 0,17
G3–G4 7 3 3 1 1,71 ± 0,29
TNM Staging      
I (T1 N0 M0) 15 12 2 1 1,26 ± 0,15
II (T2 N0 M0) 5 2 2 1 1,8 ± 0,37
III (T1 N1 M1) (T2 N1 M0) (T3 N0 M0) (T3 N1 M0) 7 4 2 1 1,57 ± 0,29
IV (T4 N0 M0) (T4 N1 M0) (Any T Any N M+) 3 1 1 1 2,00 ± 0,57
  1. The statistical evaluation of immunohistochemical results has been compared to clinical reports, pathological findings and follow-up data. No statistically significant correlation between MDR-1 expression and sex, age, tumour size, tumour stage and histological grade has been obtained.
  2. SEM: standard error of mean; Score 1 (0–20% of positive cells); Score 2 (21–40% of positive cells); Score 3 (≥ 40% of positive cells).