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Table 2 Optimised radiotherapy (hyperfractionation or acceleration) with or without simultaneous chemotherapy using cisplatin, carboplatin, mitomycin C, and 5-FU as single drug or combinations of 5-FU with one of the other drugs (Group 1b, no significant difference in overall treatment time between treatment arms)

From: A meta-analysis of hyperfractionated and accelerated radiotherapy and combined chemotherapy and radiotherapy regimens in unresected locally advanced squamous cell carcinoma of the head and neck

   control arm experimental arm   
publication trial # dose [Gy] RT time [days] dose [Gy] RT time [days] DDP Carbo 5-FU FA MMC Stage 4 [%] neck N3 [%]
Jeremic [33] 11 77 49 77 49 210      82 18
Brizel [34] 12 75 42 70 40 120   6000     13
Wendt [35] 13 70.2 56 70.2 56 180   4200 1350    14
Staar [36] 14 69.4 38 69.4 38   700 6000    96 10
Dobrowsky [37] 15 55.3 17 55.3 17      20 82 13
Budach [12] 16 77.6 42 70.4 42    3000   20 94.5 14
  1. DDP = cisplatin cumulative dose [mg/m2]; Carbo = carboplatin cumulative dose [mg/m2]; 5-FU = 5-fluorouracil cumulative dose [mg/m2]; FA = folinic acid; MMC = mitomycin C cumulative dose [mg/m2]