Figure 3From: A meta-analysis of hyperfractionated and accelerated radiotherapy and combined chemotherapy and radiotherapy regimens in unresected locally advanced squamous cell carcinoma of the head and neckDifference of survival comparing altered fractionated radiotherapy with altered fractionated radiotherapy plus chemotherapy using combinations of 5-FU with cisplatin or mitomycin C (Group 1c). This group of trials showed a relevant difference/prolongation in overall treatment time (delta 7 – 28 days) between standard and experimental treatment arm, caused by split course treatment or rapidly alternating radio-chemotherapy. OS = Overall survival; * = 95% confidence limits of 2 year overall survival; delta months = differences of median overall survival; LCL = lower confidence limit of median survival; UCL = upper confidence limit of median survival; N = number of patients.Back to article page