Figure 6

Kaplan-Meier survival curves for patients with p53 wildtype (solid line) or mutant (dashed line) tumors using gene expression-based p53 functional category or mutation status. Overall survival analysis comparing the two gene-expression based dendrogram groups (tumors in Figure 5A vs. tumors in Figure 5B) yielded a highly significant difference in survival, which compares favorably with mutation status. Both analyses used 66 tumor samples and included 26 events. Survival analysis on a separate data set (Chang et al., 2005) including 337 tumors and 79 events (C) also yielded highly significant differences based on gene expression classification.