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Table 3 Odds ratios for breast cancer by dose, frequency, and duration of exposure to celecoxib, rofecoxib, aspirin, and ibuprofen.

From: Reduction in the risk of human breast cancer by selective cyclooxygenase-2 (COX-2) inhibitors

Compounda Dose Frequency of Use Multivariate ORb(95% CI)
Celecoxib 200 mg Daily 0.17 (0.03–0.83)
Rofecoxib 25 mg Daily 0.36 (0.14–0.91)
Aspirin 325 mg 2–3 weekly 1.02 (0.30–3.57)
   >3 weekly 0.39 (0.22–0.72)
    trend (p < 0.05)
Ibuprofen 200 mg 2–3 weekly 0.59 (0.21–1.67)
   >3 weekly 0.28 (0.13–0.61)
    trend (p < 0.01)
  1. aMinimum duration of exposure: 2 years for celecoxib or rofecoxib, 5 years for aspirin or ibuprofen.
  2. bMultivariate odds ratios are adjusted for continuous variables (age and body mass) and categorical variables (parity, menopausal status, family history, smoking, and alcohol intake).