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Table 3 Comparison between reliability of MCA (*≥11 U/mL or **≥15 U/mL cut-off values) – CA15.3 and CEA-TPA-CA15.3 associations with or without an accurate history during intensive post-operative follow-up with tumour markers of 289 breast cancer patients.

From: Intensive post-operative follow-up of breast cancer patients with tumour markers: CEA, TPA or CA15.3 vs MCA and MCA-CA15.3 vs CEA-TPA-CA15.3 panel in the early detection of distant metastases

  Tumour marker panel
Reliability CEA-TPA-CA15.3 *MCA-CA15.3 CEA-TPA-CA15.3 **MCA-CA15.3
Sensitivity % 53 (53) 68 (68) 74 (74) 58 (58)
Specificity % 96 (69) 84 (40) 96 (69) 92 (71)
Accuracy % 92.5 (68) 82.5 (42) 94 (69.5) 90 (41)
NPV % 96 (95) 97 (94) 98 (97) 97 (92)
PPV% 48 (11) 24 (8) 56 (15) 37 (7)
  1. Numbers into brackets refer to dynamic evaluation of tumour markers without an accurate history and laboratory examinations.