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Table 1 Sensitivity of MCA (*≥11 or **≥15 U/mL cut-off values), CEA, TPA, CA15.3 in the early detection of 19 relapses during an intensive post-operative follow-up with tumour markers.

From: Intensive post-operative follow-up of breast cancer patients with tumour markers: CEA, TPA or CA15.3 vs MCA and MCA-CA15.3 vs CEA-TPA-CA15.3 panel in the early detection of distant metastases

  CE or PI of tumour markers as the initial pathological finding of relapse
Tumour marker type aRelapses (total, n) Sensitivity (%) Tumour marker increase Lead time (months) m + sd (range)
    type n  
*MCA 13 68 CE
PI
8
5
7.1 ± 6.8
(0–22)
CEA 2 10 CE
PI
0
2
2.0 ± 2.8
(0–4)
TPA 5 26 CE
PI
3
2
3.2 ± 4.4
(0–9)
CA15.3 6 32 CE
PI
5
1
4.7 ± 5.8
(0–14)
**MCA 10 53 CE
PI
7
3
6.5 ± 6.8
(0–18)
CEA 3 16 PI 3 7.3 ± 9.4
(0–18)
TPA 8 42 CE
PI
6
2
2.9 ± 4.0
(0–9)
CA15.3 6 32 CE
PI
5
1
4.7 ± 5.8
(0–14)
  1. aTotal number of patients = 18; one patient after radical removal by surgery of a single metastatic lesion relapsed (also see Result section). Therefore, percentages are calculated on 19 relapses; CE = constant elevation; PI = progressive increase.