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Table 2 The average Mean Cell Survival (MCS) of the 17 LCLs at different drug concentrations, expressed as the Ratio of Maximum Achieved Plasma Concentration (RMAPC)

From: Cytotoxic drug sensitivity of Epstein-Barr virus transformed lymphoblastoid B-cells

Group 1 Vincristine Epirubicin
   64× dilution 16× dilution 4× dilution 1× no dilution   64× dilution 16× dilution 4× dilution 1× no dilution
  RMAPC 0.018 0.071 0.282 1.128 RMAPC 0.003 0.012 0.046 0.184
  MCS 81.498 46.541 20.776 18.995 MCS 85.206 65.736 29.435 16.306
  SD 27.995 25.737 15.258 12.209 SD 15.548 23.394 13.593 11.314
  Paclitaxel Methotrexate
  RMAPC 0.020 0.081 0.326 1.303 RMAPC 0.001 0.004 0.014 0.057
  MCS 48.119 29.999 24.653 23.148 MCS 76.618 44.824 32.924 29.314
  SD 28.435 17.418 12.869 13.364 SD 22.796 25.843 15.590 16.455
Group 2 Gemcitabin Dactinomycin
  RMAPC 0.035 0.140 0.561 2.242 RMAPC 0.066 0.262 1.050 4.200
  MCS 49.354 38.411 27.808 23.784 MCS 86.206 54.700 20.520 16.465
  SD 34.718 30.034 16.945 12.153 SD 16.701 22.386 13.642 8.370
  5-Flurouracil Vinorelbine
  RMAPC 0.012 0.047 0.188 0.752 RMAPC 0.156 0.625 2.501 10.005
  MCS 74.861 58.001 42.337 30.505 MCS 82.833 42.823 25.176 24.683
  SD 23.686 22.987 21.370 20.645 SD 18.131 23.930 16.506 14.634
  Doxorubicin Daunorubicin
  RMAPC 0.028 0.112 0.447 1.789 RMAPC 0.133 0.531 2.126 8.502
  MCS 82.503 52.477 28.292 11.499 MCS 83.171 61.159 25.940 20.439
  SD 21.753 24.867 22.314 10.301 SD 21.886 25.402 23.933 17.961
  Etoposide Docetaxel
  RMAPC 0.130 0.521 2.083 8.333 RMAPC 0.260 1.042 4.166 16.665
  MCS 56.281 35.375 25.315 16.778 MCS 32.990 23.036 23.866 26.331
  SD 21.045 19.983 15.497 11.166 SD 22.690 17.587 16.810 19.810
Group 3 Cytarabine 6-Mercaptopurine
  RMAPC 0.121 0.482 1.929 7.716 RMAPC 0.543 2.170 8.680 34.720
  MCS 87.321 79.450 48.255 40.124 MCS 84.450 78.834 62.325 55.419
  SD 17.396 22.850 26.423 26.315 SD 22.147 16.514 29.820 32.858
  Oxaliplatin Cladribine
  RMAPC 0.020 0.081 0.325 1.301 RMAPC 0.366 1.462 5.850 23.399
  MCS 87.951 84.477 83.331 73.511 MCS 102.832 101.241 72.497 52.237
  SD 21.010 26.545 21.839 30.744 SD 8.130 11.160 26.804 29.545
  Asparaginase Chlorambucil
  RMAPC 0.015 0.058 0.232 0.930 RMAPC 2.646 10.586 42.342 169.370
  MCS 92.021 91.570 90.371 82.978 MCS 89.903 71.879 13.225 11.099
  SD 13.718 13.222 18.153 15.919 SD 17.578 26.506 10.994 7.527
  Cyclophosphamide Topotecan
  RMAPC 0.014 0.056 0.224 0.896 RMAPC 6.194 24.777 99.107 396.429
  MCS 86.670 93.412 89.498 84.041 MCS 93.897 72.802 23.250 24.784
  SD 21.910 18.833 17.832 17.920 SD 19.406 21.275 16.659 21.380
  Ifosphamide Carboplatin
  RMAPC 0.009 0.037 0.147 0.588 RMAPC 2.814 11.257 45.027 180.108
  MCS 92.729 95.906 90.101 88.518 MCS 91.805 79.175 77.962 52.322
  SD 16.694 14.965 15.299 16.677 SD 16.670 30.927 22.065 31.295
  Hydroxyurea Bleomycin
  RMAPC 0.031 0.124 0.496 1.984 RMAPC 2.078 8.311 33.245 132.979
  MCS 95.118 96.489 86.340 68.134 MCS 90.007 88.553 82.168 69.803
  SD 19.595 13.933 19.759 24.782 SD 19.294 17.678 19.720 16.686
  Vinblastine Streptozotocin
  RMAPC 2.603 10.413 41.650 166.600 RMAPC no Cmax data was found
  MCS 81.507 53.331 28.885 21.323 MCS 95.430 92.335 89.919 87.805
  SD 25.921 25.678 17.941 15.889 SD 15.828 18.710 14.094 22.637
  Bortezomib MG-132
  RMAPC 0.162 0.648 2.590 10.361 RMAPC not used in clinical practice
  MCS 93.119 81.671 75.498 28.700 MCS 87.345 96.374 88.097 27.045
  SD 13.779 21.572 19.617 26.948 SD 13.980 17.493 16.974 24.310
  Prednisolone      
  RMAPC 4.8 19.23077 76.92308 307.6923      
  MCS 75.55877 76.25595 62.46537 37.23379      
  SD 4.647172 11.09091 13.97021 11.65414      
  1. Group 1. Highly effective drugs: RMAPC < 0.3; MCS < 30%
  2. Group 2. Partially effective drugs: RMAPC between 0.3 and 1, MCS < 60%
  3. Group 3. Ineffective drugs: RMAPC > 1 or MCS > 60%
  4. SD: standard deviation in mean cell survival