Celecoxib decreases prostaglandin E2concentrations in nipple aspirate fluid from high risk postmenopausal women and women with breast cancer

Table 4 Effect of Menopausal Status on Median PGE₂ Concentrations in ng/mL in NAF¹

	Before (N)	After (N)	Washout (N)	P value
				Before v. After (N)	After v. Washout (N)	Before v. Washout (N)
Menopausal Population
*High risk*
Pre-	15.72 (11)	36.06 (11)	27.64 (11)	0.17 (11)	0.76 (11)	0.04 (11)
Post-	5.88 (15)²	6.81 (11)	5.57 (11)	0.03 (11)	0.77 (10)	0.03 (11)
*P value*	0.18	0.04	0.003
*Cancer*
Pre-	15.2 (3)	2.40 (3)	NA	0.25 (3)
Post-	10.9 (8)	8.27 (8)	NA	0.11 (8)
*P value*	1.00	0.61

1: Abbreviations: NAF: nipple aspirate fluid; N: sample size; NA: not applicable.
2: Before treatment median PGE₂ for the 11 subjects with an after treatment comparison value was 8.33, which was significantly higher than the after treatment group.

ISSN: 1471-2407